Video-assisted thoracoscopic surgery thymectomy versus open thymectomy in patients with myasthenia gravis: a meta-analysis

Background: Video-assisted thoracoscopic surgery (VATS) thymectomy has become a feasible treatment for myasthenia gravis (MG) in recent years. The objective of the present meta-analysis was to evaluate the perioperative characteristics, safety, and completely stable remission rate in patients with M...

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Bibliographic Details
Published in:Acta chirurgica belgica 2016-10, Vol.116 (5), p.282-288
Main Authors: Qi, Kang, Wang, Bo, Wang, Bin, Zhang, Lian-Bin, Chu, Xiang-Yang
Format: Article
Language:English
Subjects:
Female
Follow-Up Studies
Humans
Length of Stay
Male
Meta-analysis
myasthenia gravis
Myasthenia Gravis - diagnosis
Myasthenia Gravis - surgery
Operative Time
Postoperative Complications - epidemiology
Postoperative Complications - physiopathology
Risk Assessment
Sternotomy - adverse effects
Sternotomy - methods
Thoracic Surgery, Video-Assisted - adverse effects
Thoracic Surgery, Video-Assisted - methods
thymectomy
Thymectomy - adverse effects
Thymectomy - methods
Thymoma - diagnosis
Thymoma - surgery
Treatment Outcome
video-assisted thoracoscopic surgery
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Summary:Background: Video-assisted thoracoscopic surgery (VATS) thymectomy has become a feasible treatment for myasthenia gravis (MG) in recent years. The objective of the present meta-analysis was to evaluate the perioperative characteristics, safety, and completely stable remission rate in patients with MG who received VATS or open thymectomy (OT). Methods: We searched PubMed, Embase, ScienceDirect, Web of Science, and CNKI for related articles using combinations of the search terms video-assisted thoracoscopic thymectomy, transsternal thymectomy, and MG. The inter-study heterogeneity was assessed by χ 2 -based Q statistics, and the extent of inconsistency was generated by I 2 statistics. Results: A total of 12 studies with 1173 patients were included, and there was no difference in the operation time (p = 0.08) and ICU time (p = 0.14) between the two groups, but VATS thymectomy was associated with less intra-operation blood loss and hospital time (p 
ISSN:0001-5458
DOI:10.1080/00015458.2016.1176419