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Premature mammary gland involution with repeated corticosterone injection in interleukin 10-deficient mice
IL-10 is important for stress modulation, and impaired IL-10 function can cause premature mammary gland involution and pup alopecia. Recently, we found that maternal stress could induce premature mammary gland involution in interleukin 10 knock out (IL-10 −/− ) mice. To elucidate correlation between...
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Published in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2016-12, Vol.80 (12), p.2318-2324 |
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creator | Hwang, Woo-Sung Bae, Ji-Hyun Yeom, Su-Cheong |
description | IL-10 is important for stress modulation, and impaired IL-10 function can cause premature mammary gland involution and pup alopecia.
Recently, we found that maternal stress could induce premature mammary gland involution in interleukin 10 knock out (IL-10
−/−
) mice. To elucidate correlation between stress, IL-10, and mammary gland involution, corticosterone was injected into the lactating wild type and IL-10-deficient mice and assessed mammary gland phenotype. Repetitive corticosterone injection developed premature mammary gland involution only in B6.IL-10
−/−
mice; moreover, it induced alopecia in nursing pups. Corticosterone injection induced several typical changes such as mammary gland epithelial cell apoptosis, macrophage infiltration, fat deposition in adipocyte, STAT3 phosphorylation, and upregulation of tyrosine hydroxylase gene in adrenal gland. Overall incidence of pup alopecia and mammary gland involution was relatively high in corticosterone than control B6.IL-10
−/−
group (57% vs. 20%). Our finding demonstrates that IL-10 is important for stress modulation, and B6.Il-10
−/−
with corticosterone has several advantage such as simple to establish, well-defined onset of mammary gland involution, high incidence, and inducing pup alopecia. |
doi_str_mv | 10.1080/09168451.2016.1214556 |
format | article |
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Recently, we found that maternal stress could induce premature mammary gland involution in interleukin 10 knock out (IL-10
−/−
) mice. To elucidate correlation between stress, IL-10, and mammary gland involution, corticosterone was injected into the lactating wild type and IL-10-deficient mice and assessed mammary gland phenotype. Repetitive corticosterone injection developed premature mammary gland involution only in B6.IL-10
−/−
mice; moreover, it induced alopecia in nursing pups. Corticosterone injection induced several typical changes such as mammary gland epithelial cell apoptosis, macrophage infiltration, fat deposition in adipocyte, STAT3 phosphorylation, and upregulation of tyrosine hydroxylase gene in adrenal gland. Overall incidence of pup alopecia and mammary gland involution was relatively high in corticosterone than control B6.IL-10
−/−
group (57% vs. 20%). Our finding demonstrates that IL-10 is important for stress modulation, and B6.Il-10
−/−
with corticosterone has several advantage such as simple to establish, well-defined onset of mammary gland involution, high incidence, and inducing pup alopecia.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1080/09168451.2016.1214556</identifier><identifier>PMID: 27485250</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adipocytes - cytology ; Adipocytes - drug effects ; Alopecia - etiology ; Animals ; Apoptosis - drug effects ; Corticosterone - pharmacology ; Female ; interleukin 10 ; Interleukin-10 - deficiency ; Lactation - drug effects ; Macrophages - cytology ; Macrophages - drug effects ; mammary gland involution ; Mammary Glands, Animal - drug effects ; Mammary Glands, Animal - physiology ; Mice ; Mice, Inbred C57BL ; stress</subject><ispartof>Bioscience, biotechnology, and biochemistry, 2016-12, Vol.80 (12), p.2318-2324</ispartof><rights>2016 Japan Society for Bioscience, Biotechnology, and Agrochemistry 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c437t-155801611da1ec025d39188fba08279109495ef80c2a6da65988e0c6e45eb3b23</citedby><cites>FETCH-LOGICAL-c437t-155801611da1ec025d39188fba08279109495ef80c2a6da65988e0c6e45eb3b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27485250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Woo-Sung</creatorcontrib><creatorcontrib>Bae, Ji-Hyun</creatorcontrib><creatorcontrib>Yeom, Su-Cheong</creatorcontrib><title>Premature mammary gland involution with repeated corticosterone injection in interleukin 10-deficient mice</title><title>Bioscience, biotechnology, and biochemistry</title><addtitle>Biosci Biotechnol Biochem</addtitle><description>IL-10 is important for stress modulation, and impaired IL-10 function can cause premature mammary gland involution and pup alopecia.
Recently, we found that maternal stress could induce premature mammary gland involution in interleukin 10 knock out (IL-10
−/−
) mice. To elucidate correlation between stress, IL-10, and mammary gland involution, corticosterone was injected into the lactating wild type and IL-10-deficient mice and assessed mammary gland phenotype. Repetitive corticosterone injection developed premature mammary gland involution only in B6.IL-10
−/−
mice; moreover, it induced alopecia in nursing pups. Corticosterone injection induced several typical changes such as mammary gland epithelial cell apoptosis, macrophage infiltration, fat deposition in adipocyte, STAT3 phosphorylation, and upregulation of tyrosine hydroxylase gene in adrenal gland. Overall incidence of pup alopecia and mammary gland involution was relatively high in corticosterone than control B6.IL-10
−/−
group (57% vs. 20%). Our finding demonstrates that IL-10 is important for stress modulation, and B6.Il-10
−/−
with corticosterone has several advantage such as simple to establish, well-defined onset of mammary gland involution, high incidence, and inducing pup alopecia.</description><subject>Adipocytes - cytology</subject><subject>Adipocytes - drug effects</subject><subject>Alopecia - etiology</subject><subject>Animals</subject><subject>Apoptosis - drug effects</subject><subject>Corticosterone - pharmacology</subject><subject>Female</subject><subject>interleukin 10</subject><subject>Interleukin-10 - deficiency</subject><subject>Lactation - drug effects</subject><subject>Macrophages - cytology</subject><subject>Macrophages - drug effects</subject><subject>mammary gland involution</subject><subject>Mammary Glands, Animal - drug effects</subject><subject>Mammary Glands, Animal - physiology</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>stress</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAQgIMouj5-gtKjl66ZNGnTmyK-QNCDnkM2nWrWtlmTVPHfm7qrR2FghuGbGeYj5BjoHKikZ7SGUnIBc0ahnAMDLkS5RWZQ8Cova15tk9nE5BO0R_ZDWFKaGgJ2yR6ruBRM0BlZPnrsdRw9Zr3ue-2_spdOD01mhw_XjdG6Ifu08TXzuEIdscmM89EaFyJ6N2Dilmh-MDtF6nY4vqUaaN5ga43FIWa9NXhIdlrdBTza5APyfH31dHmb3z_c3F1e3OeGF1XMQQiZXgJoNKChTDRFDVK2C00lq2qgNa8FtpIapstGl6KWEqkpkQtcFAtWHJDT9d6Vd-8jhqh6Gwx26S10Y1AgWVlxRqVMqFijxrsQPLZq5e0kQQFVk2b1q1lNmtVGc5o72ZwYFz02f1O_XhNwvgbs0Drf60_nu0ZF_dU533o9GBtU8f-Nb_UHjTM</recordid><startdate>201612</startdate><enddate>201612</enddate><creator>Hwang, Woo-Sung</creator><creator>Bae, Ji-Hyun</creator><creator>Yeom, Su-Cheong</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201612</creationdate><title>Premature mammary gland involution with repeated corticosterone injection in interleukin 10-deficient mice</title><author>Hwang, Woo-Sung ; Bae, Ji-Hyun ; Yeom, Su-Cheong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c437t-155801611da1ec025d39188fba08279109495ef80c2a6da65988e0c6e45eb3b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adipocytes - cytology</topic><topic>Adipocytes - drug effects</topic><topic>Alopecia - etiology</topic><topic>Animals</topic><topic>Apoptosis - drug effects</topic><topic>Corticosterone - pharmacology</topic><topic>Female</topic><topic>interleukin 10</topic><topic>Interleukin-10 - deficiency</topic><topic>Lactation - drug effects</topic><topic>Macrophages - cytology</topic><topic>Macrophages - drug effects</topic><topic>mammary gland involution</topic><topic>Mammary Glands, Animal - drug effects</topic><topic>Mammary Glands, Animal - physiology</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>stress</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Woo-Sung</creatorcontrib><creatorcontrib>Bae, Ji-Hyun</creatorcontrib><creatorcontrib>Yeom, Su-Cheong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Bioscience, biotechnology, and biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Woo-Sung</au><au>Bae, Ji-Hyun</au><au>Yeom, Su-Cheong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Premature mammary gland involution with repeated corticosterone injection in interleukin 10-deficient mice</atitle><jtitle>Bioscience, biotechnology, and biochemistry</jtitle><addtitle>Biosci Biotechnol Biochem</addtitle><date>2016-12</date><risdate>2016</risdate><volume>80</volume><issue>12</issue><spage>2318</spage><epage>2324</epage><pages>2318-2324</pages><issn>0916-8451</issn><eissn>1347-6947</eissn><abstract>IL-10 is important for stress modulation, and impaired IL-10 function can cause premature mammary gland involution and pup alopecia.
Recently, we found that maternal stress could induce premature mammary gland involution in interleukin 10 knock out (IL-10
−/−
) mice. To elucidate correlation between stress, IL-10, and mammary gland involution, corticosterone was injected into the lactating wild type and IL-10-deficient mice and assessed mammary gland phenotype. Repetitive corticosterone injection developed premature mammary gland involution only in B6.IL-10
−/−
mice; moreover, it induced alopecia in nursing pups. Corticosterone injection induced several typical changes such as mammary gland epithelial cell apoptosis, macrophage infiltration, fat deposition in adipocyte, STAT3 phosphorylation, and upregulation of tyrosine hydroxylase gene in adrenal gland. Overall incidence of pup alopecia and mammary gland involution was relatively high in corticosterone than control B6.IL-10
−/−
group (57% vs. 20%). Our finding demonstrates that IL-10 is important for stress modulation, and B6.Il-10
−/−
with corticosterone has several advantage such as simple to establish, well-defined onset of mammary gland involution, high incidence, and inducing pup alopecia.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>27485250</pmid><doi>10.1080/09168451.2016.1214556</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adipocytes - cytology Adipocytes - drug effects Alopecia - etiology Animals Apoptosis - drug effects Corticosterone - pharmacology Female interleukin 10 Interleukin-10 - deficiency Lactation - drug effects Macrophages - cytology Macrophages - drug effects mammary gland involution Mammary Glands, Animal - drug effects Mammary Glands, Animal - physiology Mice Mice, Inbred C57BL stress |
title | Premature mammary gland involution with repeated corticosterone injection in interleukin 10-deficient mice |
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