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Premature mammary gland involution with repeated corticosterone injection in interleukin 10-deficient mice

IL-10 is important for stress modulation, and impaired IL-10 function can cause premature mammary gland involution and pup alopecia. Recently, we found that maternal stress could induce premature mammary gland involution in interleukin 10 knock out (IL-10 −/− ) mice. To elucidate correlation between...

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Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2016-12, Vol.80 (12), p.2318-2324
Main Authors: Hwang, Woo-Sung, Bae, Ji-Hyun, Yeom, Su-Cheong
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description IL-10 is important for stress modulation, and impaired IL-10 function can cause premature mammary gland involution and pup alopecia. Recently, we found that maternal stress could induce premature mammary gland involution in interleukin 10 knock out (IL-10 −/− ) mice. To elucidate correlation between stress, IL-10, and mammary gland involution, corticosterone was injected into the lactating wild type and IL-10-deficient mice and assessed mammary gland phenotype. Repetitive corticosterone injection developed premature mammary gland involution only in B6.IL-10 −/− mice; moreover, it induced alopecia in nursing pups. Corticosterone injection induced several typical changes such as mammary gland epithelial cell apoptosis, macrophage infiltration, fat deposition in adipocyte, STAT3 phosphorylation, and upregulation of tyrosine hydroxylase gene in adrenal gland. Overall incidence of pup alopecia and mammary gland involution was relatively high in corticosterone than control B6.IL-10 −/− group (57% vs. 20%). Our finding demonstrates that IL-10 is important for stress modulation, and B6.Il-10 −/− with corticosterone has several advantage such as simple to establish, well-defined onset of mammary gland involution, high incidence, and inducing pup alopecia.
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subjects Adipocytes - cytology
Adipocytes - drug effects
Alopecia - etiology
Animals
Apoptosis - drug effects
Corticosterone - pharmacology
Female
interleukin 10
Interleukin-10 - deficiency
Lactation - drug effects
Macrophages - cytology
Macrophages - drug effects
mammary gland involution
Mammary Glands, Animal - drug effects
Mammary Glands, Animal - physiology
Mice
Mice, Inbred C57BL
stress
title Premature mammary gland involution with repeated corticosterone injection in interleukin 10-deficient mice
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