Serum vitamin D level is negatively associated with carotid atherosclerosis in Korean adults

The present study investigated the associations between serum vitamin D levels and carotid intima-media thickness (CIMT), carotid plaque and atherosclerosis in 71 Korean adults. CIMT and the presence of carotid plaque were assessed with a high-resolution B-mode ultrasound system, and carotid atheros...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2017-02, Vol.68 (1), p.90-96
Main Authors: Choi, Yeon-Kyeong, Song, Sang-Wook, Shin, Bo-Ra, Kim, Jeong-Ah, Kim, Ha-Na
Format: Article
Language:English
Subjects:
25-hydroxyvitamin D
25-Hydroxyvitamin D 2 - blood
Adults
Arteriosclerosis
Atherosclerosis
Atherosclerosis - diagnostic imaging
Atherosclerosis - epidemiology
Atherosclerosis - ethnology
Atherosclerosis - etiology
Biomarkers - blood
Calcifediol - blood
Cardiovascular diseases
Carotid Intima-Media Thickness
carotid plaque
Carotid Stenosis - diagnostic imaging
Carotid Stenosis - epidemiology
Carotid Stenosis - ethnology
Carotid Stenosis - etiology
Confidence intervals
Cross-Sectional Studies
Female
Food science
Health risk assessment
Heart diseases
Humans
Logistic Models
Male
Mass Screening
Middle Aged
Nutrition
Nutritional Status - ethnology
Prevalence
Republic of Korea - epidemiology
Risk Factors
Self Report
Severity of Illness Index
Supplements
Ultrasound
Vitamin D
vitamin D deficiency
Vitamin D Deficiency - blood
Vitamin D Deficiency - ethnology
Vitamin D Deficiency - physiopathology
Vitamin deficiency
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Summary:The present study investigated the associations between serum vitamin D levels and carotid intima-media thickness (CIMT), carotid plaque and atherosclerosis in 71 Korean adults. CIMT and the presence of carotid plaque were assessed with a high-resolution B-mode ultrasound system, and carotid atherosclerosis was defined as a mean CIMT value >0.9 mm or the presence of carotid plaque. A vitamin D deficiency was associated with the presence of carotid plaque (adjusted odds ratio [aOR]: 9.25, 95% confidence interval [CI]: 1.52-56.3; p = 0.016). As serum vitamin D levels increased, the presence of high-risk carotid plaque decreased (aOR: 0.84, 95%CI: 0.72-0.99; p = 0.039). Serum vitamin D levels was negatively associated with carotid atherosclerosis (aOR: 0.86, 95%CI: 0.76-0.97; p = 0.018). Further studies are needed to investigate whether vitamin D supplementation would be effective for the prevention of atherosclerosis and cardiovascular diseases.
ISSN:0963-7486
1465-3478
DOI:10.1080/09637486.2016.1216526