Quality of life of HIV-infected patients who switch antiretroviral medication due to side effects or other reasons

Objective: The objective of this study was to investigate changes in health-related quality of life (HRQOL) among HIV patients following switch from a first- to second-line antiretroviral therapy (ART) regimen. Research design and methods: This was an observational study of adult HIV patients in the...

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Published in:Current medical research and opinion 2016-12, Vol.32 (12), p.2039-2046
Main Authors: Maiese, Eric M., Johnson, Phaedra T., Bancroft, Tim, Goolsby Hunter, Alyssa, Wu, Albert W.
Format: Article
Language:English
Subjects:
Adult
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - adverse effects
Anti-HIV Agents - therapeutic use
Antiretroviral therapy
Female
HIV
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - psychology
Humans
Longitudinal Studies
Male
Middle Aged
QOL
Quality of Life
Side effects
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container_issue 12
container_start_page 2039
container_title Current medical research and opinion
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creator Maiese, Eric M.
Johnson, Phaedra T.
Bancroft, Tim
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description Objective: The objective of this study was to investigate changes in health-related quality of life (HRQOL) among HIV patients following switch from a first- to second-line antiretroviral therapy (ART) regimen. Research design and methods: This was an observational study of adult HIV patients in the US at 35 academic and community health centers. Patients were required to be switching an antiretroviral regimen for the first time at the enrollment visit. Patients were assigned to a study cohort based on whether the switch was due to treatment-related side effects or for any other reason as reported by their physician. Patients completed the Medical Outcomes Study-Human Immunodeficiency Virus (MOS-HIV) health survey, the Depression, Anxiety, and Stress Scale Short Form (DASS-21), and the Human Immunodeficiency Virus Treatment Satisfaction Questionnaire-status (HIVTSQs) at the enrollment visit (baseline) and a follow-up survey was completed approximately 4 weeks later. The within cohort change in survey measures from baseline to follow-up was assessed by two-sample paired t-test. Results: Patients who switched their ART regimen due to treatment-related side effects (n = 50) had statistically significant improvements (p 
doi_str_mv 10.1080/03007995.2016.1227776
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Research design and methods: This was an observational study of adult HIV patients in the US at 35 academic and community health centers. Patients were required to be switching an antiretroviral regimen for the first time at the enrollment visit. Patients were assigned to a study cohort based on whether the switch was due to treatment-related side effects or for any other reason as reported by their physician. Patients completed the Medical Outcomes Study-Human Immunodeficiency Virus (MOS-HIV) health survey, the Depression, Anxiety, and Stress Scale Short Form (DASS-21), and the Human Immunodeficiency Virus Treatment Satisfaction Questionnaire-status (HIVTSQs) at the enrollment visit (baseline) and a follow-up survey was completed approximately 4 weeks later. The within cohort change in survey measures from baseline to follow-up was assessed by two-sample paired t-test. Results: Patients who switched their ART regimen due to treatment-related side effects (n = 50) had statistically significant improvements (p &lt; .05, baseline to follow-up) in mean Physical and Mental Health Summary scores (MOS-HIV scale) and in all three HIVTSQ summary scores. Patients who switched for other reasons (n = 44) did not experience statistically significant improvements in these same measures. Conclusions: HIV patients whose regimen was switched due to treatment-related side effects experienced an improvement in QOL following the switch. Physicians should take the potential impact on QOL into consideration when deciding on a switch in ART regimen, particularly when patients are intolerant of their current treatment. The results are based on a patient survey and may have been influenced by recall and response bias.</description><identifier>ISSN: 0300-7995</identifier><identifier>EISSN: 1473-4877</identifier><identifier>DOI: 10.1080/03007995.2016.1227776</identifier><identifier>PMID: 27552553</identifier><language>eng</language><publisher>England: Taylor &amp; Francis</publisher><subject>Adult ; Anti-HIV Agents - administration &amp; dosage ; Anti-HIV Agents - adverse effects ; Anti-HIV Agents - therapeutic use ; Antiretroviral therapy ; Female ; HIV ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; HIV Infections - psychology ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; QOL ; Quality of Life ; Side effects</subject><ispartof>Current medical research and opinion, 2016-12, Vol.32 (12), p.2039-2046</ispartof><rights>2016 Informa UK Limited, trading as Taylor &amp; Francis Group 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c366t-708d322b474e1b15127e08a1c13a75870070b9d459790efc827baaa83b7f77233</citedby><cites>FETCH-LOGICAL-c366t-708d322b474e1b15127e08a1c13a75870070b9d459790efc827baaa83b7f77233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27552553$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Maiese, Eric M.</creatorcontrib><creatorcontrib>Johnson, Phaedra T.</creatorcontrib><creatorcontrib>Bancroft, Tim</creatorcontrib><creatorcontrib>Goolsby Hunter, Alyssa</creatorcontrib><creatorcontrib>Wu, Albert W.</creatorcontrib><title>Quality of life of HIV-infected patients who switch antiretroviral medication due to side effects or other reasons</title><title>Current medical research and opinion</title><addtitle>Curr Med Res Opin</addtitle><description>Objective: The objective of this study was to investigate changes in health-related quality of life (HRQOL) among HIV patients following switch from a first- to second-line antiretroviral therapy (ART) regimen. Research design and methods: This was an observational study of adult HIV patients in the US at 35 academic and community health centers. Patients were required to be switching an antiretroviral regimen for the first time at the enrollment visit. Patients were assigned to a study cohort based on whether the switch was due to treatment-related side effects or for any other reason as reported by their physician. Patients completed the Medical Outcomes Study-Human Immunodeficiency Virus (MOS-HIV) health survey, the Depression, Anxiety, and Stress Scale Short Form (DASS-21), and the Human Immunodeficiency Virus Treatment Satisfaction Questionnaire-status (HIVTSQs) at the enrollment visit (baseline) and a follow-up survey was completed approximately 4 weeks later. The within cohort change in survey measures from baseline to follow-up was assessed by two-sample paired t-test. Results: Patients who switched their ART regimen due to treatment-related side effects (n = 50) had statistically significant improvements (p &lt; .05, baseline to follow-up) in mean Physical and Mental Health Summary scores (MOS-HIV scale) and in all three HIVTSQ summary scores. Patients who switched for other reasons (n = 44) did not experience statistically significant improvements in these same measures. Conclusions: HIV patients whose regimen was switched due to treatment-related side effects experienced an improvement in QOL following the switch. Physicians should take the potential impact on QOL into consideration when deciding on a switch in ART regimen, particularly when patients are intolerant of their current treatment. 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Research design and methods: This was an observational study of adult HIV patients in the US at 35 academic and community health centers. Patients were required to be switching an antiretroviral regimen for the first time at the enrollment visit. Patients were assigned to a study cohort based on whether the switch was due to treatment-related side effects or for any other reason as reported by their physician. Patients completed the Medical Outcomes Study-Human Immunodeficiency Virus (MOS-HIV) health survey, the Depression, Anxiety, and Stress Scale Short Form (DASS-21), and the Human Immunodeficiency Virus Treatment Satisfaction Questionnaire-status (HIVTSQs) at the enrollment visit (baseline) and a follow-up survey was completed approximately 4 weeks later. The within cohort change in survey measures from baseline to follow-up was assessed by two-sample paired t-test. Results: Patients who switched their ART regimen due to treatment-related side effects (n = 50) had statistically significant improvements (p &lt; .05, baseline to follow-up) in mean Physical and Mental Health Summary scores (MOS-HIV scale) and in all three HIVTSQ summary scores. Patients who switched for other reasons (n = 44) did not experience statistically significant improvements in these same measures. Conclusions: HIV patients whose regimen was switched due to treatment-related side effects experienced an improvement in QOL following the switch. Physicians should take the potential impact on QOL into consideration when deciding on a switch in ART regimen, particularly when patients are intolerant of their current treatment. The results are based on a patient survey and may have been influenced by recall and response bias.</abstract><cop>England</cop><pub>Taylor &amp; Francis</pub><pmid>27552553</pmid><doi>10.1080/03007995.2016.1227776</doi><tpages>8</tpages></addata></record>
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source Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)
subjects Adult
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - adverse effects
Anti-HIV Agents - therapeutic use
Antiretroviral therapy
Female
HIV
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV Infections - psychology
Humans
Longitudinal Studies
Male
Middle Aged
QOL
Quality of Life
Side effects
title Quality of life of HIV-infected patients who switch antiretroviral medication due to side effects or other reasons
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