Early mortality in children with acute lymphoblastic leukemia in a developing country: the role of malnutrition at diagnosis. A multicenter cohort MIGICCL study

The role of malnutrition at diagnosis as a predictor of early mortality in Mexican leukemia children remains controversial. The objective of present study was to investigate whether malnutrition was a predictor of early mortality during the first year of treatment in Mexican acute lymphoblastic leuk...

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Published in:Leukemia & lymphoma 2017-04, Vol.58 (4), p.898-908
Main Authors: Martín-Trejo, Jorge Alfonso, Núñez-Enríquez, Juan Carlos, Fajardo-Gutiérrez, Arturo, Medina-Sansón, Aurora, Flores-Lujano, Janet, Jiménez-Hernández, Elva, Amador-Sanchez, Raquel, Peñaloza-Gonzalez, José Gabriel, Alvarez-Rodriguez, Francisco Javier, Bolea-Murga, Victoria, Espinosa-Elizondo, Rosa Martha, de Diego Flores-Chapa, José, Pérez-Saldivar, Maria Luisa, Rodriguez-Zepeda, María del Carmen, Dorantes-Acosta, Elisa María, Núñez-Villegas, Nora Nancy, Velazquez-Aviña, Martha Margarita, Torres-Nava, José Refugio, Reyes-Zepeda, Nancy Carolina, González-Bonilla, César Raúl, Flores-Villegas, Luz Victoria, Rangel-López, Angélica, Rivera-Luna, Roberto, Paredes-Aguilera, Rogelio, Cárdenas-Cardós, Rocío, Martínez-Avalos, Armando, Gil-Hernández, Ana Elena, Duarte-Rodríguez, David Aldebarán, Mejía-Aranguré, Juan Manuel
Format: Article
Language:English
Subjects:
Adolescent
Age Factors
Body Weights and Measures
Child
Child, Preschool
children
Comorbidity
Developing Countries
Female
Humans
Infant
Infant, Newborn
Leukemia
Male
malnutrition
Malnutrition - diagnosis
Malnutrition - epidemiology
Mexico - epidemiology
mortality
Population Surveillance
Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality
Precursor Cell Lymphoblastic Leukemia-Lymphoma - therapy
Prevalence
prognosis
Proportional Hazards Models
Remission Induction
Socioeconomic Factors
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Summary:The role of malnutrition at diagnosis as a predictor of early mortality in Mexican leukemia children remains controversial. The objective of present study was to investigate whether malnutrition was a predictor of early mortality during the first year of treatment in Mexican acute lymphoblastic leukemia (ALL) children through the first population-based study. A total of 794 newly diagnosed ALL pediatric patients from public hospitals of Mexico City were enrolled. A multivariate Cox proportional hazards regression model was constructed and adjusted by patient's age at diagnosis, gender, hospital of treatment, and socioeconomic status. Early mortality was high (12.1%) and malnutrition by different indicators was not associated with mortality at induction phase and at 6th month; a high risk of dying (RR = 2.08; 95% CI: 1.08-4.01) was observed in the group of malnourished children with a high-risk ALL.
ISSN:1042-8194
1029-2403
DOI:10.1080/10428194.2016.1219904