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Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population
Background and aim: Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aims of the present study were to determine the prevalence of vitamin D deficiency and to identify clinical and epidemiological variables associated with vitamin D deficiency in an outpatient population with...
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| Published in: | Scandinavian journal of gastroenterology 2017-01, Vol.52 (1), p.100-106 |
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| container_end_page | 106 |
| container_issue | 1 |
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| container_title | Scandinavian journal of gastroenterology |
| container_volume | 52 |
| creator | Frigstad, Svein Oskar Høivik, Marte Jahnsen, Jørgen Dahl, Sandra Rinne Cvancarova, Milada Grimstad, Tore Berset, Ingrid Prytz Huppertz-Hauss, Gert Hovde, Øistein Torp, Roald Bernklev, Tomm Moum, Bjørn Jelsness-Jørgensen, Lars-Petter |
| description | Background and aim: Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aims of the present study were to determine the prevalence of vitamin D deficiency and to identify clinical and epidemiological variables associated with vitamin D deficiency in an outpatient population with IBD.
Methods: Participants were recruited from nine hospitals in the southeastern and western regions of Norway as part of an observational, multicentre study from March 2013 to April 2014. Clinical and epidemiological data were collected by interview and from medical records. All analyses of serum 25-hydroxyvitamin D (25-OH-D) were performed in the same laboratory.
Results: In total, 49% (200/408) of the patients had a 25-OH-D concentration |
| doi_str_mv | 10.1080/00365521.2016.1233577 |
| format | article |
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Methods: Participants were recruited from nine hospitals in the southeastern and western regions of Norway as part of an observational, multicentre study from March 2013 to April 2014. Clinical and epidemiological data were collected by interview and from medical records. All analyses of serum 25-hydroxyvitamin D (25-OH-D) were performed in the same laboratory.
Results: In total, 49% (200/408) of the patients had a 25-OH-D concentration <50 nmol/L, including 53% (122/230) of the Crohn's disease (CD) patients and 44% (78/178) of the ulcerative colitis (UC) patients. In CD patients, disease activity, measured as the HBI, was inversely associated with vitamin D deficiency. No such association was observed with the Simple Clinical Colitis Activity Index (SCCAI) scores in UC, but in UC patients, vitamin D deficiency was associated with elevated faecal calprotectin >100 mg/kg. In patients with CD, there were significantly more relapses during the previous year in patients with vitamin D deficiency.
Conclusions: Vitamin D deficiency was common, especially in CD, and was associated with increased disease activity, a relapsing disease course and higher inflammatory activity.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/00365521.2016.1233577</identifier><identifier>PMID: 27603182</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adolescent ; Adult ; Aged ; Colitis, Ulcerative - blood ; Colitis, Ulcerative - complications ; Crohn Disease - blood ; Crohn Disease - complications ; Disease Progression ; epidemiology ; Female ; Humans ; Inflammatory bowel disease ; Logistic Models ; Male ; Middle Aged ; Multivariate Analysis ; Norway - epidemiology ; Outpatients ; Risk Factors ; Severity of Illness Index ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; vitamin D deficiency ; Vitamin D Deficiency - epidemiology ; Young Adult</subject><ispartof>Scandinavian journal of gastroenterology, 2017-01, Vol.52 (1), p.100-106</ispartof><rights>2016 Informa UK Limited, trading as Taylor & Francis Group 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c479t-f47953de86a3b2a840ac077066f3d86d049a7418bcec96c22077da6ae7a7e4c43</citedby><cites>FETCH-LOGICAL-c479t-f47953de86a3b2a840ac077066f3d86d049a7418bcec96c22077da6ae7a7e4c43</cites><orcidid>0000-0002-0104-465X ; 0000-0001-7841-608X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27603182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Frigstad, Svein Oskar</creatorcontrib><creatorcontrib>Høivik, Marte</creatorcontrib><creatorcontrib>Jahnsen, Jørgen</creatorcontrib><creatorcontrib>Dahl, Sandra Rinne</creatorcontrib><creatorcontrib>Cvancarova, Milada</creatorcontrib><creatorcontrib>Grimstad, Tore</creatorcontrib><creatorcontrib>Berset, Ingrid Prytz</creatorcontrib><creatorcontrib>Huppertz-Hauss, Gert</creatorcontrib><creatorcontrib>Hovde, Øistein</creatorcontrib><creatorcontrib>Torp, Roald</creatorcontrib><creatorcontrib>Bernklev, Tomm</creatorcontrib><creatorcontrib>Moum, Bjørn</creatorcontrib><creatorcontrib>Jelsness-Jørgensen, Lars-Petter</creatorcontrib><title>Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Background and aim: Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aims of the present study were to determine the prevalence of vitamin D deficiency and to identify clinical and epidemiological variables associated with vitamin D deficiency in an outpatient population with IBD.
Methods: Participants were recruited from nine hospitals in the southeastern and western regions of Norway as part of an observational, multicentre study from March 2013 to April 2014. Clinical and epidemiological data were collected by interview and from medical records. All analyses of serum 25-hydroxyvitamin D (25-OH-D) were performed in the same laboratory.
Results: In total, 49% (200/408) of the patients had a 25-OH-D concentration <50 nmol/L, including 53% (122/230) of the Crohn's disease (CD) patients and 44% (78/178) of the ulcerative colitis (UC) patients. In CD patients, disease activity, measured as the HBI, was inversely associated with vitamin D deficiency. No such association was observed with the Simple Clinical Colitis Activity Index (SCCAI) scores in UC, but in UC patients, vitamin D deficiency was associated with elevated faecal calprotectin >100 mg/kg. In patients with CD, there were significantly more relapses during the previous year in patients with vitamin D deficiency.
Conclusions: Vitamin D deficiency was common, especially in CD, and was associated with increased disease activity, a relapsing disease course and higher inflammatory activity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Colitis, Ulcerative - blood</subject><subject>Colitis, Ulcerative - complications</subject><subject>Crohn Disease - blood</subject><subject>Crohn Disease - complications</subject><subject>Disease Progression</subject><subject>epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Norway - epidemiology</subject><subject>Outpatients</subject><subject>Risk Factors</subject><subject>Severity of Illness Index</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>vitamin D deficiency</subject><subject>Vitamin D Deficiency - epidemiology</subject><subject>Young Adult</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhi1ERbeFnwDykUsWf8R2lhOotKVSBRfgas3aE2TkxMFOWO2_x9FuOXKxPfLzzmgeQl5ztuWsY-8Yk1opwbeCcb3lQkplzDOy4YqJxhjWPSeblWlW6JJclfKLMaZMu3tBLoXRTPJObEj-EWYYwkg_UY99cAFHd6S1DmMfYRhgTvlI9-mAkfpQEAq-p1PGPxAriRRGv5Y-uAqWNQj0S8oH_BlgpGmZJ5hrz5lOaVpifafxJbnoIRZ8db6vyfe72283n5vHr_cPNx8fG9ea3dz09VTSY6dB7gV0LQPH6mJa99J32rN2B6bl3d6h22knRP30oAENGGxdK6_J21PfKaffC5bZDqE4jBFGTEuxvFNcGCEUr6g6oS6nUjL2dsphgHy0nNlVt33SbVfd9qy75t6cRyz7Af2_1JPfCnw4AVVnygMcUo7eznCMKfcZRheKlf-f8RcU55Bz</recordid><startdate>20170102</startdate><enddate>20170102</enddate><creator>Frigstad, Svein Oskar</creator><creator>Høivik, Marte</creator><creator>Jahnsen, Jørgen</creator><creator>Dahl, Sandra Rinne</creator><creator>Cvancarova, Milada</creator><creator>Grimstad, Tore</creator><creator>Berset, Ingrid Prytz</creator><creator>Huppertz-Hauss, Gert</creator><creator>Hovde, Øistein</creator><creator>Torp, Roald</creator><creator>Bernklev, Tomm</creator><creator>Moum, Bjørn</creator><creator>Jelsness-Jørgensen, Lars-Petter</creator><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-0104-465X</orcidid><orcidid>https://orcid.org/0000-0001-7841-608X</orcidid></search><sort><creationdate>20170102</creationdate><title>Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population</title><author>Frigstad, Svein Oskar ; Høivik, Marte ; Jahnsen, Jørgen ; Dahl, Sandra Rinne ; Cvancarova, Milada ; Grimstad, Tore ; Berset, Ingrid Prytz ; Huppertz-Hauss, Gert ; Hovde, Øistein ; Torp, Roald ; Bernklev, Tomm ; Moum, Bjørn ; Jelsness-Jørgensen, Lars-Petter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c479t-f47953de86a3b2a840ac077066f3d86d049a7418bcec96c22077da6ae7a7e4c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Colitis, Ulcerative - blood</topic><topic>Colitis, Ulcerative - complications</topic><topic>Crohn Disease - blood</topic><topic>Crohn Disease - complications</topic><topic>Disease Progression</topic><topic>epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Norway - epidemiology</topic><topic>Outpatients</topic><topic>Risk Factors</topic><topic>Severity of Illness Index</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>vitamin D deficiency</topic><topic>Vitamin D Deficiency - epidemiology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Frigstad, Svein Oskar</creatorcontrib><creatorcontrib>Høivik, Marte</creatorcontrib><creatorcontrib>Jahnsen, Jørgen</creatorcontrib><creatorcontrib>Dahl, Sandra Rinne</creatorcontrib><creatorcontrib>Cvancarova, Milada</creatorcontrib><creatorcontrib>Grimstad, Tore</creatorcontrib><creatorcontrib>Berset, Ingrid Prytz</creatorcontrib><creatorcontrib>Huppertz-Hauss, Gert</creatorcontrib><creatorcontrib>Hovde, Øistein</creatorcontrib><creatorcontrib>Torp, Roald</creatorcontrib><creatorcontrib>Bernklev, Tomm</creatorcontrib><creatorcontrib>Moum, Bjørn</creatorcontrib><creatorcontrib>Jelsness-Jørgensen, Lars-Petter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Frigstad, Svein Oskar</au><au>Høivik, Marte</au><au>Jahnsen, Jørgen</au><au>Dahl, Sandra Rinne</au><au>Cvancarova, Milada</au><au>Grimstad, Tore</au><au>Berset, Ingrid Prytz</au><au>Huppertz-Hauss, Gert</au><au>Hovde, Øistein</au><au>Torp, Roald</au><au>Bernklev, Tomm</au><au>Moum, Bjørn</au><au>Jelsness-Jørgensen, Lars-Petter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>2017-01-02</date><risdate>2017</risdate><volume>52</volume><issue>1</issue><spage>100</spage><epage>106</epage><pages>100-106</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><abstract>Background and aim: Vitamin D deficiency is common in inflammatory bowel disease (IBD). The aims of the present study were to determine the prevalence of vitamin D deficiency and to identify clinical and epidemiological variables associated with vitamin D deficiency in an outpatient population with IBD.
Methods: Participants were recruited from nine hospitals in the southeastern and western regions of Norway as part of an observational, multicentre study from March 2013 to April 2014. Clinical and epidemiological data were collected by interview and from medical records. All analyses of serum 25-hydroxyvitamin D (25-OH-D) were performed in the same laboratory.
Results: In total, 49% (200/408) of the patients had a 25-OH-D concentration <50 nmol/L, including 53% (122/230) of the Crohn's disease (CD) patients and 44% (78/178) of the ulcerative colitis (UC) patients. In CD patients, disease activity, measured as the HBI, was inversely associated with vitamin D deficiency. No such association was observed with the Simple Clinical Colitis Activity Index (SCCAI) scores in UC, but in UC patients, vitamin D deficiency was associated with elevated faecal calprotectin >100 mg/kg. In patients with CD, there were significantly more relapses during the previous year in patients with vitamin D deficiency.
Conclusions: Vitamin D deficiency was common, especially in CD, and was associated with increased disease activity, a relapsing disease course and higher inflammatory activity.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>27603182</pmid><doi>10.1080/00365521.2016.1233577</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-0104-465X</orcidid><orcidid>https://orcid.org/0000-0001-7841-608X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Scandinavian journal of gastroenterology, 2017-01, Vol.52 (1), p.100-106 |
| issn | 0036-5521 1502-7708 |
| language | eng |
| recordid | cdi_pubmed_primary_27603182 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adolescent Adult Aged Colitis, Ulcerative - blood Colitis, Ulcerative - complications Crohn Disease - blood Crohn Disease - complications Disease Progression epidemiology Female Humans Inflammatory bowel disease Logistic Models Male Middle Aged Multivariate Analysis Norway - epidemiology Outpatients Risk Factors Severity of Illness Index Vitamin D - analogs & derivatives Vitamin D - blood vitamin D deficiency Vitamin D Deficiency - epidemiology Young Adult |
| title | Vitamin D deficiency in inflammatory bowel disease: prevalence and predictors in a Norwegian outpatient population |
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