A lysosome-targeted fluorescent sensor for the detection of glutathione in cells with an extremely fast response

A highly sensitive and selective Rhodamine B-based fluorescent sensor, RhB-1 , for glutathione (GSH) was easily synthesized. An extremely fast detection response time of 10 s, which is the fastest one ever reported, is achieved in aqueous solutions over a wide pH range with large enhancement of emis...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (77), p.11579-11582
Main Authors: Huang, Rong, Wang, Bei-Bei, Si-Tu, Xing-Ming, Gao, Tao, Wang, Fang-Fang, He, Huan, Fan, Xiao-Yang, Jiang, Feng-Lei, Liu, Yi
Format: Article
Language:English
Subjects:
Aqueous solutions
Emission
Fluorescence
Glutathione
Lysosomes
Response time
Sensors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A highly sensitive and selective Rhodamine B-based fluorescent sensor, RhB-1 , for glutathione (GSH) was easily synthesized. An extremely fast detection response time of 10 s, which is the fastest one ever reported, is achieved in aqueous solutions over a wide pH range with large enhancement of emission intensity. The sensor detects GSH in cells and selectively accumulates in lysosomes. A Rhodamine B-based off-on fluorescent sensor ( RhB-1 ) for GSH has an extremely fast detection response time of 10 s in aqueous solutions.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc06750f