VEGF-A and VEGFR1 SNPs associate with preeclampsia in a Philippine population

The vascular endothelial growth factor (VEGF) family is important for establishing normal pregnancy, and related single nucleotide polymorphisms (SNPs) are implicated in abnormal placentation and preeclampsia. We evaluated the association between preeclampsia and several VEGF SNPs among Filipinos, a...

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Bibliographic Details
Published in:Clinical and experimental hypertension (1993) 2016-01, Vol.38 (7), p.578-585
Main Authors: Amosco, Melissa D., Villar, Van Anthony M., Naniong, Justin Michael A., David-Bustamante, Lara Marie G., Jose, Pedro A., Palmes-Saloma, Cynthia P.
Format: Article
Language:English
Subjects:
Adult
Alleles
Association study
Case-Control Studies
Female
Genotype
Humans
Odds Ratio
Philippines - ethnology
Placentation - genetics
Polymorphism, Single Nucleotide
Pre-Eclampsia - epidemiology
Pre-Eclampsia - genetics
preeclampsia
Pregnancy
single nucleotide polymorphism
Vascular Endothelial Growth Factor A - blood
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor C - genetics
Vascular Endothelial Growth Factor Receptor-1 - genetics
Vascular Endothelial Growth Factor Receptor-3 - genetics
VEGF
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Summary:The vascular endothelial growth factor (VEGF) family is important for establishing normal pregnancy, and related single nucleotide polymorphisms (SNPs) are implicated in abnormal placentation and preeclampsia. We evaluated the association between preeclampsia and several VEGF SNPs among Filipinos, an ethnically distinct group with high prevalence of preeclampsia. The genotypes and allelic variants were determined in a case-control study (191 controls and 165 preeclampsia patients) through SNP analysis of VEGF-A (rs2010963, rs3025039) and VEGF-C (rs7664413) and their corresponding receptors VEGFR1 (rs722503, rs12584067, rs7335588) and VEGFR3 (rs307826) from venous blood DNA. VEGF-A rs3025039 C allele has been shown to associate with preeclampsia (odds ratio of 1.648 (1.03-2.62)), while the T allele bestowed an additive effect for the maintenance of normal, uncomplicated pregnancy and against the development of preeclampsia (odds ratio of 0.62 (0.39-0.98)). VEGFR1 rs722503 is associated with preeclampsia occurring at or after the age of 40 years. The results showed that genetic variability of VEGF-A and VEGFR1 are important in the etiology of preeclampsia among Filipinos.
ISSN:1064-1963
1525-6006
DOI:10.3109/10641963.2016.1174252