Cord blood erythropoietin and cord blood nucleated red blood cells for prediction of adverse neonatal outcome associated with maternal obesity in term pregnancy: prospective cohort study

Objective: To determine the adverse pregnancy outcomes associated with maternal pre-pregnancy overweight and obesity and we measure cord blood erythropoietin and NRBC count as indices of hypoxia and predictors of neonatal outcome. Study design: This prospective cohort study was done in Minia Univers...

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Published in:The journal of maternal-fetal & neonatal medicine 2017-09, Vol.30 (18), p.2237-2242
Main Authors: Ibrahim, Mahmoud H., Moustafa, Asmaa N., Saedii, Ahmed A. Fadil, Hassan, Ebtesam E.
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Case-Control Studies
Cesarean Section - statistics & numerical data
Erythroblasts - pathology
erythropoietin
Erythropoietin - blood
Female
Fetal Blood
Humans
Infant, Newborn
Maternal obesity
Middle Aged
nucleated red blood cells
Obesity - complications
Pregnancy
Pregnancy Complications
Pregnancy Outcome
Prospective Studies
ROC Curve
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Summary:Objective: To determine the adverse pregnancy outcomes associated with maternal pre-pregnancy overweight and obesity and we measure cord blood erythropoietin and NRBC count as indices of hypoxia and predictors of neonatal outcome. Study design: This prospective cohort study was done in Minia University Hospital, carried out from May 2015 to April 2016. Two hundred and seventy full-term neonates born to mothers of various body mass indices were included. Excluded were neonates with major factors known to be associated with a potential increase in fetal erythropoiesis. Pre-pregnancy maternal BMI was calculated from maternally reported weight and height. Cord blood erythropoietin and nucleated red blood cells were measured. Results: There is a significant increase of various adverse pregnancy outcomes as cesarean section. Postpartum hemorrhage and macrosomia with the increase of maternal pre-pregnancy BMI. Significant positive correlations between cord blood erythropoietin and nucleated red blood cells with maternal BMI. Conclusion: The increase in the maternal pre-pregnancy BMI is associated with poor pregnancy outcomes. Cord blood erythropoietin and nucleated red blood cells can predict the poor neonatal outcome.
ISSN:1476-7058
1476-4954
DOI:10.1080/14767058.2016.1243101