Measurement of neural respiratory drive via parasternal intercostal electromyography in healthy adult subjects

Neural respiratory drive, quantified by the parasternal intercostal muscle electromyogram (EMGpara), provides a sensitive measure of respiratory system load-capacity balance. Reference values for EMGpara-based measures are lacking and the influence of individual anthropometric characteristics is not...

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Bibliographic Details
Published in:Physiological measurement 2016-11, Vol.37 (11), p.2050-2063
Main Authors: MacBean, V, Hughes, C, Nicol, G, Reilly, C C, Rafferty, G F
Format: Article
Language:English
Subjects:
Adult
Brain Stem - cytology
Brain Stem - physiology
Electromyography
Female
healthy subjects
Healthy Volunteers
human
Humans
Male
Muscle Strength
Muscles - physiology
neural respiratory drive
Respiration
respiratory muscles
respiratory physiology
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Summary:Neural respiratory drive, quantified by the parasternal intercostal muscle electromyogram (EMGpara), provides a sensitive measure of respiratory system load-capacity balance. Reference values for EMGpara-based measures are lacking and the influence of individual anthropometric characteristics is not known. EMGpara is conventionally expressed as a percentage of that obtained during a maximal inspiratory effort (EMGpara%max), leading to difficulty in applying the technique in subjects unable to reliably perform such manoeuvres. To measure EMGpara in a large, unselected cohort of healthy adult subjects in order to evaluate relevant technical and anthropometric factors. Surface second intercostal space EMGpara was measured during resting breathing and maximal inspiratory efforts in 63 healthy adult subjects, median (IQR) age 31.0 (25.0-47.0) years, 28 males. Detailed anthropometry, spirometry and respiratory muscle strength were also recorded. Median (IQR EMGpara was 4.95 (3.35-6.93) µV, EMGpara%max 4.95 (3.39-8.65)% and neural respiratory drive index (NRDI, the product of EMGpara%max and respiratory rate) was 73.62 (46.41-143.92) %.breath/min. EMGpara increased significantly to 6.28 (4.26-9.93) µV (p  
ISSN:0967-3334
1361-6579
DOI:10.1088/0967-3334/37/11/2050