Strategies for CT tissue segmentation for Monte Carlo calculations in nuclear medicine dosimetry

Purpose: CT images are used for patient specific Monte Carlo treatment planning in radionuclide therapy. The authors investigated the impact of tissue classification, CT image segmentation, and CT errors on Monte Carlo calculated absorbed dose estimates in nuclear medicine. Methods: CT errors as a f...

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Bibliographic Details
Published in:Medical physics (Lancaster) 2016-12, Vol.43 (12), p.6507-6516
Main Authors: Braad, P. E. N., Andersen, T., Hansen, S. B., Høilund-Carlsen, P. F.
Format: Article
Language:English
Subjects:
Calibration
cancer
Computed tomography
Computerised tomographs
computerised tomography
Digital computing or data processing equipment or methods, specially adapted for specific applications
Dose‐volume analysis
dosimetry
Humans
Image data processing or generation, in general
Image Processing, Computer-Assisted - methods
image reconstruction
image segmentation
Kidneys
Lungs
Male
Medical image noise
medical image processing
Medical image reconstruction
Monte Carlo
Monte Carlo Method
Monte Carlo methods
Nuclear Medicine
PET/CT
phantoms
Phantoms, Imaging
Radiation Dosage
radiation therapy
Radiometry
radionuclide therapy
Radiotherapy Planning, Computer-Assisted
Reconstruction
Scintigraphy
Segmentation
SPECT/CT
Thyroid Neoplasms - diagnostic imaging
Thyroid Neoplasms - pathology
Thyroid Neoplasms - radiotherapy
Tissues
Tomography, X-Ray Computed - methods
tumours
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Summary:Purpose: CT images are used for patient specific Monte Carlo treatment planning in radionuclide therapy. The authors investigated the impact of tissue classification, CT image segmentation, and CT errors on Monte Carlo calculated absorbed dose estimates in nuclear medicine. Methods: CT errors as a function of patient size, CT reconstruction, and tube current modulation methods were assessed in a phantom experiment on a clinical CT system. The impact of tissue segmentation methods and CT number variations on EGSnrc Monte Carlo calculated absorbed dose distributions was assessed for 99mTc and 131I in the ICRP/ICRU male phantom and in a patient PET/CT-scanned with 124I prior to radioiodine therapy. Results: CT number variations
ISSN:0094-2405
2473-4209
DOI:10.1118/1.4967267