Serum substance P concentrations to predict oocyte maturation index and clinical pregnancy

Aim: The aim of this study was to assess the predictive value of serum substance P (SP) concentrations on oocyte maturation and clinical pregnancy. Methods: Ninety-three women with unexplained infertility underwent intracytoplasmic sperm injection (ICSI) cycles. Antagonist protocol was started for e...

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Bibliographic Details
Published in:Gynecological endocrinology 2017-03, Vol.33 (3), p.203-207
Main Authors: Sahin, Yavuz, Özkaya, Enis, Kayatas Eser, Semra, Kutlu, Tayfun, Sanverdi, Ilhan, Tunali, Gulden, Karateke, Ates
Format: Article
Language:English
Subjects:
Adult
Assisted reproduction
Biomarkers - blood
Chorionic Gonadotropin - pharmacology
Cross-Sectional Studies
Female
Hospitals, Teaching
Humans
implantation
In Vitro Oocyte Maturation Techniques
Infertility, Female - blood
Infertility, Female - therapy
Luteinizing Hormone - pharmacology
maturation index
Oocyte Retrieval
Oogenesis - drug effects
Ovulation Induction
Predictive Value of Tests
Pregnancy
Pregnancy Rate
Pregnancy Tests
ROC Curve
Sperm Injections, Intracytoplasmic
substance P
Substance P - blood
Turkey
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Summary:Aim: The aim of this study was to assess the predictive value of serum substance P (SP) concentrations on oocyte maturation and clinical pregnancy. Methods: Ninety-three women with unexplained infertility underwent intracytoplasmic sperm injection (ICSI) cycles. Antagonist protocol was started for each participant and at the day of oocyte pick up, serum samples were obtained from each participant to assess SP concentrations, and these concentrations were utilized to predict mature/total oocyte ratio and clinical pregnancy. Results: SP concentration was a significant predictor for mature/total oocyte ratio > 0.75 and clinical pregnancy. In correlation analyses, maturation index was significantly correlated with FSH (r= −0.226, p = 0.03), estradiol (r = 0.239, p = 0.021), peak estradiol (r = 0.414, p 
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2016.1254611