Pseudoephedrine accumulation in renal failure (case report)

Neuropsychiatric complications, such as metabolic encephalopathy, are common occurrences in end-stage renal disease (ESRD) patients. Frequently, metabolic encephalopathy develops in relationship to the multiple pharmacologic therapies routinely employed in this population. Such polypharmacy often le...

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Bibliographic Details
Published in:The American journal of the medical sciences 1989-10, Vol.298 (4), p.261-263
Main Authors: SICA, D. A, COMSTOCK, T. J
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drug intoxications. Doping
Ephedrine - adverse effects
Ephedrine - blood
Humans
Kidney Failure, Chronic - metabolism
Kidney Failure, Chronic - therapy
Male
Medical sciences
Middle Aged
Myoclonus - chemically induced
Pharmacology. Drug treatments
Renal Dialysis
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Summary:Neuropsychiatric complications, such as metabolic encephalopathy, are common occurrences in end-stage renal disease (ESRD) patients. Frequently, metabolic encephalopathy develops in relationship to the multiple pharmacologic therapies routinely employed in this population. Such polypharmacy often leads to adverse drug reactions, drug-drug interactions, or dosage error. In this regard, over-the-counter (OTC) medications are commonly perceived as being "somewhat benign" when, in fact, their potential for adverse effect may be significant. The authors describe the course of a 64-year-old hemodialysis patient who became intoxicated on conventional doses of pseudoephedrine only to regain neurologic integrity upon discontinuation of the medication.
ISSN:0002-9629
1538-2990
DOI:10.1097/00000441-198910000-00010