Immediate and residual effects of low-dose nandrolone decanoate and treadmill training on adipose and reproductive tissues of male Wistar rats

• Published in: Archives of physiology and biochemistry 2017-05, Vol.123 (2), p.68-77
• Main Authors: Rodrigues, Josilene M., Oliveira, Vinicius P. P., P. Furlan, Julia, Munhoz, Ana Claudia, S. Rempel, Marcelo R., Brito, Marcia N., Brito, Nilton A., Pedrosa, Maria M. D., M. Costa, Cecília E.
• Format: Article
• Language: English
• Subjects: Adipose Tissue - drug effects; Adipose Tissue - physiology; Animals; detraining; lipid; Male; Muscle, Skeletal - drug effects; Muscle, Skeletal - physiology; Nandrolone - analogs & derivatives; Nandrolone - pharmacology; Nandrolone decanoate; Physical Conditioning, Animal - methods; rat; Rats; Rats, Wistar; Testis - drug effects; Testis - physiology; training
• ISSN: 1381-3455; 1744-4160
• DOI: 10.1080/13813455.2016.1260592

Context: Residual effects after nandrolone decanoate (ND) treatment are not reported. Objective: Immediate and residual effects of low-dose ND and treadmill training were investigated. Materials and methods: Male rats were trained and/or ND-treated for four weeks and the assessments were made after this period or four weeks later. Results: The groups did not differ in final plasma glucose or AUC of the ivGTT, but hyperinsulinemia was noticed in some trained/treated groups. Training with ND increased muscle mass and ND decreased the reproductive structures. Decreased fat with training was reversed by detraining. Discussion: The anabolic action of ND on skeletal muscle was enhanced by training. Fat and lipid changes were more linked to training/detraining, but the effects of ND on the reproductive structures persisted after treatment. Conclusions: The effects of training on fat and muscle were not maintained after detraining, but low-dose ND had persistent effects on the reproductive structures.