The effects of IL-1A and IL-6 genes polymorphisms on gene expressions, hormonal and biochemical parameters in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a multifactorial disease characterised by chronic inflammation. We aimed to investigate an association between IL-1A and IL-6 gene polymorphisms and both hormonal/biochemical parameters and levels of IL-1A and IL-6. A total of 103 women diagnosed with PCOS accordi...

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Bibliographic Details
Published in:Journal of obstetrics and gynaecology 2017-04, Vol.37 (3), p.358-362
Main Authors: Eser, Betul, Islimye Taskin, Mine, Hismiogullari, Adnan Adil, Aksit, Hasan, Bodur, Abdurrahman Said
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Biomarkers - blood
Case-Control Studies
Chi-Square Distribution
Expression
Female
Follicle Stimulating Hormone - blood
Gene Expression
Gene Frequency
gene polymorphisms
Genes
Humans
Insulin Resistance
Interleukin-1alpha - blood
Interleukin-1alpha - genetics
Interleukin-6 - blood
Interleukin-6 - genetics
interleukins
Luteinizing Hormone - blood
Obesity - complications
Obesity - physiopathology
Ovaries
Polycystic ovary syndrome
Polycystic Ovary Syndrome - blood
Polycystic Ovary Syndrome - complications
Polycystic Ovary Syndrome - genetics
Polymorphism
Polymorphism, Single Nucleotide
Testosterone - blood
Young Adult
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Summary:Polycystic ovary syndrome (PCOS) is a multifactorial disease characterised by chronic inflammation. We aimed to investigate an association between IL-1A and IL-6 gene polymorphisms and both hormonal/biochemical parameters and levels of IL-1A and IL-6. A total of 103 women diagnosed with PCOS according to ESHRE/ASRM criteria were investigated. The patients were divided into two groups as obese and non-obese. IL-1A and IL-6 genes polymorphisms as well as hormonal/biochemical parameters and levels of IL-1A and IL-6 were analysed in the same groups. Serum IL-1A and IL-6 levels were found to increase both in obese and non-obese groups. However, there was no association between IL-1A level and IL-1A polymorphism. A relationship was detected between H score, FSH, LH, total testosterone, HDL-C and TG levels and CG + GG genotypes of IL-6. Furthermore, an association was found between IL-6 levels and CC genotype of IL-6 in the obese PCOS patients. The abnormalities in hormonal/biochemical parameters detected in Turkish PCOS patients may be related with IL-6 gene polymorphism rather than IL-1A.
ISSN:0144-3615
1364-6893
DOI:10.1080/01443615.2016.1256966