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Determination of serum aflatoxin B 1 -lysine to evaluate the efficacy of an aflatoxin-adsorbing feed additive in pigs fed an aflatoxin B 1 -contaminated diet
In this study, serum aflatoxin B (AFB )-lysine was determined in order to evaluate the in vivo efficacy of a hydrated sodium calcium aluminosilicate (HSCAS) in pigs fed AFB . Twenty-four 49-day-old crossbred barrows were maintained in individual cages and allowed ad libitum access to feed and water....
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| Published in: | Mycotoxin research 2017-05, Vol.33 (2), p.93 |
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| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
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| container_issue | 2 |
| container_start_page | 93 |
| container_title | Mycotoxin research |
| container_volume | 33 |
| creator | Di Gregorio, Mayra Carraro Jager, Alessandra Vincenzi Souto, Pollyana Cristina Maggio Castro Costa, Aline Alves Rottinghaus, George Edwin Passarelli, Danielle Budiño, Fabio Enrique Lemos Corassin, Carlos Humberto Oliveira, Carlos Augusto Fernandes |
| description | In this study, serum aflatoxin B
(AFB
)-lysine was determined in order to evaluate the in vivo efficacy of a hydrated sodium calcium aluminosilicate (HSCAS) in pigs fed AFB
. Twenty-four 49-day-old crossbred barrows were maintained in individual cages and allowed ad libitum access to feed and water. A completely randomized design was used with six animals assigned to each of four dietary treatments for 21 days as follows: (A) basal diet (BD), (B) BD supplemented with 0.5 % HSCAS, (C) BD supplemented with 1.1 mg/kg AFB
, and (D) BD supplemented with 0.5 % HSCAS and 1.1 mg/kg AFB
. HSCAS was able to alleviate the toxic effects of AFB
on pigs and reduce (P |
| doi_str_mv | 10.1007/s12550-016-0267-5 |
| format | article |
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(AFB
)-lysine was determined in order to evaluate the in vivo efficacy of a hydrated sodium calcium aluminosilicate (HSCAS) in pigs fed AFB
. Twenty-four 49-day-old crossbred barrows were maintained in individual cages and allowed ad libitum access to feed and water. A completely randomized design was used with six animals assigned to each of four dietary treatments for 21 days as follows: (A) basal diet (BD), (B) BD supplemented with 0.5 % HSCAS, (C) BD supplemented with 1.1 mg/kg AFB
, and (D) BD supplemented with 0.5 % HSCAS and 1.1 mg/kg AFB
. HSCAS was able to alleviate the toxic effects of AFB
on pigs and reduce (P < 0.05) the levels of serum AFB
-lysine. Cumulative reductions of adduct yield values, calculated through the equation [(pg AFB
-lysine/mg albumin) / (μg AFB
/kg body weight)], were 53.0, 62.8, and 72.1 after 7, 14, and 21 days of oral exposure, respectively. AFB
-lysine has potential as an AFB
-specific biomarker for diagnostic purposes and for evaluating the efficacy of chemoprotective interventions in pigs.</description><identifier>EISSN: 1867-1632</identifier><identifier>DOI: 10.1007/s12550-016-0267-5</identifier><identifier>PMID: 28035652</identifier><language>eng</language><publisher>Germany</publisher><subject>Adsorption ; Aflatoxin B1 - blood ; Aflatoxin B1 - isolation & purification ; Aluminum Silicates ; Animal Feed ; Animals ; Diet - methods ; Food Additives ; Food Contamination ; Lysine - blood ; Mycotoxins - blood ; Mycotoxins - isolation & purification ; Serum - chemistry ; Swine</subject><ispartof>Mycotoxin research, 2017-05, Vol.33 (2), p.93</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28035652$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Di Gregorio, Mayra Carraro</creatorcontrib><creatorcontrib>Jager, Alessandra Vincenzi</creatorcontrib><creatorcontrib>Souto, Pollyana Cristina Maggio Castro</creatorcontrib><creatorcontrib>Costa, Aline Alves</creatorcontrib><creatorcontrib>Rottinghaus, George Edwin</creatorcontrib><creatorcontrib>Passarelli, Danielle</creatorcontrib><creatorcontrib>Budiño, Fabio Enrique Lemos</creatorcontrib><creatorcontrib>Corassin, Carlos Humberto</creatorcontrib><creatorcontrib>Oliveira, Carlos Augusto Fernandes</creatorcontrib><title>Determination of serum aflatoxin B 1 -lysine to evaluate the efficacy of an aflatoxin-adsorbing feed additive in pigs fed an aflatoxin B 1 -contaminated diet</title><title>Mycotoxin research</title><addtitle>Mycotoxin Res</addtitle><description>In this study, serum aflatoxin B
(AFB
)-lysine was determined in order to evaluate the in vivo efficacy of a hydrated sodium calcium aluminosilicate (HSCAS) in pigs fed AFB
. Twenty-four 49-day-old crossbred barrows were maintained in individual cages and allowed ad libitum access to feed and water. A completely randomized design was used with six animals assigned to each of four dietary treatments for 21 days as follows: (A) basal diet (BD), (B) BD supplemented with 0.5 % HSCAS, (C) BD supplemented with 1.1 mg/kg AFB
, and (D) BD supplemented with 0.5 % HSCAS and 1.1 mg/kg AFB
. HSCAS was able to alleviate the toxic effects of AFB
on pigs and reduce (P < 0.05) the levels of serum AFB
-lysine. Cumulative reductions of adduct yield values, calculated through the equation [(pg AFB
-lysine/mg albumin) / (μg AFB
/kg body weight)], were 53.0, 62.8, and 72.1 after 7, 14, and 21 days of oral exposure, respectively. AFB
-lysine has potential as an AFB
-specific biomarker for diagnostic purposes and for evaluating the efficacy of chemoprotective interventions in pigs.</description><subject>Adsorption</subject><subject>Aflatoxin B1 - blood</subject><subject>Aflatoxin B1 - isolation & purification</subject><subject>Aluminum Silicates</subject><subject>Animal Feed</subject><subject>Animals</subject><subject>Diet - methods</subject><subject>Food Additives</subject><subject>Food Contamination</subject><subject>Lysine - blood</subject><subject>Mycotoxins - blood</subject><subject>Mycotoxins - isolation & purification</subject><subject>Serum - chemistry</subject><subject>Swine</subject><issn>1867-1632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqFj0tOxDAMhiMkxAyPA7BBvkAgaUmma17iAOxHnsaZ8ahNqiQd0cNwV8pLiBUr_7L_z78txKVW11qp1U3WlTFKKm2lquxKmiOx1M0stK2rhTjNea-UrW9tcyIWVaNqY021FG8PVCj1HLBwDBA9ZEpjD-g7LPGVA9yBBtlNmQNBiUAH7EYss94RkPfcYjt9cBh-IYkux7ThsAVP5ACd48IHgnnfwNs8d90f4CuljaHg5y3z2DGVc3Hssct08V3PxNXT48v9sxzGTU9uPSTuMU3rn3_qfw3vhExcxA</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Di Gregorio, Mayra Carraro</creator><creator>Jager, Alessandra Vincenzi</creator><creator>Souto, Pollyana Cristina Maggio Castro</creator><creator>Costa, Aline Alves</creator><creator>Rottinghaus, George Edwin</creator><creator>Passarelli, Danielle</creator><creator>Budiño, Fabio Enrique Lemos</creator><creator>Corassin, Carlos Humberto</creator><creator>Oliveira, Carlos Augusto Fernandes</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>201705</creationdate><title>Determination of serum aflatoxin B 1 -lysine to evaluate the efficacy of an aflatoxin-adsorbing feed additive in pigs fed an aflatoxin B 1 -contaminated diet</title><author>Di Gregorio, Mayra Carraro ; Jager, Alessandra Vincenzi ; Souto, Pollyana Cristina Maggio Castro ; Costa, Aline Alves ; Rottinghaus, George Edwin ; Passarelli, Danielle ; Budiño, Fabio Enrique Lemos ; Corassin, Carlos Humberto ; Oliveira, Carlos Augusto Fernandes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-pubmed_primary_280356523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adsorption</topic><topic>Aflatoxin B1 - blood</topic><topic>Aflatoxin B1 - isolation & purification</topic><topic>Aluminum Silicates</topic><topic>Animal Feed</topic><topic>Animals</topic><topic>Diet - methods</topic><topic>Food Additives</topic><topic>Food Contamination</topic><topic>Lysine - blood</topic><topic>Mycotoxins - blood</topic><topic>Mycotoxins - isolation & purification</topic><topic>Serum - chemistry</topic><topic>Swine</topic><toplevel>online_resources</toplevel><creatorcontrib>Di Gregorio, Mayra Carraro</creatorcontrib><creatorcontrib>Jager, Alessandra Vincenzi</creatorcontrib><creatorcontrib>Souto, Pollyana Cristina Maggio Castro</creatorcontrib><creatorcontrib>Costa, Aline Alves</creatorcontrib><creatorcontrib>Rottinghaus, George Edwin</creatorcontrib><creatorcontrib>Passarelli, Danielle</creatorcontrib><creatorcontrib>Budiño, Fabio Enrique Lemos</creatorcontrib><creatorcontrib>Corassin, Carlos Humberto</creatorcontrib><creatorcontrib>Oliveira, Carlos Augusto Fernandes</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Mycotoxin research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Di Gregorio, Mayra Carraro</au><au>Jager, Alessandra Vincenzi</au><au>Souto, Pollyana Cristina Maggio Castro</au><au>Costa, Aline Alves</au><au>Rottinghaus, George Edwin</au><au>Passarelli, Danielle</au><au>Budiño, Fabio Enrique Lemos</au><au>Corassin, Carlos Humberto</au><au>Oliveira, Carlos Augusto Fernandes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of serum aflatoxin B 1 -lysine to evaluate the efficacy of an aflatoxin-adsorbing feed additive in pigs fed an aflatoxin B 1 -contaminated diet</atitle><jtitle>Mycotoxin research</jtitle><addtitle>Mycotoxin Res</addtitle><date>2017-05</date><risdate>2017</risdate><volume>33</volume><issue>2</issue><spage>93</spage><pages>93-</pages><eissn>1867-1632</eissn><abstract>In this study, serum aflatoxin B
(AFB
)-lysine was determined in order to evaluate the in vivo efficacy of a hydrated sodium calcium aluminosilicate (HSCAS) in pigs fed AFB
. Twenty-four 49-day-old crossbred barrows were maintained in individual cages and allowed ad libitum access to feed and water. A completely randomized design was used with six animals assigned to each of four dietary treatments for 21 days as follows: (A) basal diet (BD), (B) BD supplemented with 0.5 % HSCAS, (C) BD supplemented with 1.1 mg/kg AFB
, and (D) BD supplemented with 0.5 % HSCAS and 1.1 mg/kg AFB
. HSCAS was able to alleviate the toxic effects of AFB
on pigs and reduce (P < 0.05) the levels of serum AFB
-lysine. Cumulative reductions of adduct yield values, calculated through the equation [(pg AFB
-lysine/mg albumin) / (μg AFB
/kg body weight)], were 53.0, 62.8, and 72.1 after 7, 14, and 21 days of oral exposure, respectively. AFB
-lysine has potential as an AFB
-specific biomarker for diagnostic purposes and for evaluating the efficacy of chemoprotective interventions in pigs.</abstract><cop>Germany</cop><pmid>28035652</pmid><doi>10.1007/s12550-016-0267-5</doi></addata></record> |
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| identifier | EISSN: 1867-1632 |
| ispartof | Mycotoxin research, 2017-05, Vol.33 (2), p.93 |
| issn | 1867-1632 |
| language | eng |
| recordid | cdi_pubmed_primary_28035652 |
| source | Springer Link |
| subjects | Adsorption Aflatoxin B1 - blood Aflatoxin B1 - isolation & purification Aluminum Silicates Animal Feed Animals Diet - methods Food Additives Food Contamination Lysine - blood Mycotoxins - blood Mycotoxins - isolation & purification Serum - chemistry Swine |
| title | Determination of serum aflatoxin B 1 -lysine to evaluate the efficacy of an aflatoxin-adsorbing feed additive in pigs fed an aflatoxin B 1 -contaminated diet |
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