Daily oral intake of β-cryptoxanthin ameliorates neuropathic pain

β-cryptoxanthin, a xanthophyll carotenoid, exerts preventive effects on various lifestyle-related diseases. Here, we found that daily oral administration of β-cryptoxanthin significantly ameliorated the development of tactile allodynia following spinal nerve injury but was ineffective in mechanical...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2017-05, Vol.81 (5), p.1014-1017
Main Authors: Park, Gyujin, Horie, Tetsuhiro, Iezaki, Takashi, Okamoto, Maika, Fukasawa, Kazuya, Kanayama, Takashi, Ozaki, Kakeru, Onishi, Yuki, Sugiura, Minoru, Hinoi, Eiichi
Format: Article
Language:English
Subjects:
Administration, Oral
allodynia
Animals
Beta-Cryptoxanthin - administration & dosage
Beta-Cryptoxanthin - pharmacology
Beta-Cryptoxanthin - therapeutic use
Dietary Supplements
Male
Mice
Neuralgia - drug therapy
neuropathic pain
β-cryptoxanthin
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Summary:β-cryptoxanthin, a xanthophyll carotenoid, exerts preventive effects on various lifestyle-related diseases. Here, we found that daily oral administration of β-cryptoxanthin significantly ameliorated the development of tactile allodynia following spinal nerve injury but was ineffective in mechanical allodynia in an inflammatory pain model in mice. Our results suggest that β-cryptoxanthin supplementation would be beneficial for the prophylaxis of neuropathic pain.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2017.1280661