Hydrogen Peroxide: A Potential Wound Therapeutic Target

Hydrogen peroxide (H 2 O 2 ) is a topical antiseptic used in wound cleaning which kills pathogens through oxidation burst and local oxygen production. H 2 O 2 has been reported to be a reactive biochemical molecule synthesized by various cells that influences biological behavior through multiple mec...

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Bibliographic Details
Published in:Medical principles and practice 2017-01, Vol.26 (4), p.301-308
Main Authors: Zhu, Guanya, Wang, Qi, Lu, Shuliang, Niu, Yiwen
Format: Article
Language:English
Subjects:
Animals
Anti-Infective Agents, Local - pharmacology
Antigens
Antimicrobial agents
Arthritis
Blood
Cell growth
Cytokines
Deoxyribonucleic acid
DNA
Gene expression
Growth factors
Hemostasis - drug effects
Humans
Hydrogen peroxide
Hydrogen Peroxide - pharmacology
Inflammation
Microorganisms
Neutrophils
Pathogens
Proteins
Rats
Review
Transcription factors
Wound healing
Wound Healing - drug effects
Wound Healing - physiology
Wounds and Injuries - drug therapy
Wounds and Injuries - immunology
Wounds and Injuries - physiopathology
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Summary:Hydrogen peroxide (H 2 O 2 ) is a topical antiseptic used in wound cleaning which kills pathogens through oxidation burst and local oxygen production. H 2 O 2 has been reported to be a reactive biochemical molecule synthesized by various cells that influences biological behavior through multiple mechanisms: alterations of membrane potential, generation of new molecules, and changing intracellular redox balance, which results in activation or inactivation of different signaling transduction pathways. Contrary to the traditional viewpoint that H 2 O 2 probably impairs tissue through its high oxidative property, a proper level of H 2 O 2 is considered an important requirement for normal wound healing. Although the present clinical use of H 2 O 2 is still limited to the elimination of microbial contamination and sometimes hemostasis, better understanding towards the sterilization ability and cell behavior regulatory function of H 2 O 2 within wounds will enhance the potential to exogenously augment and manipulate healing.
ISSN:1011-7571
1423-0151
DOI:10.1159/000475501