High-Throughput Automation in Chemical Process Development

High-throughput (HT) techniques built upon laboratory automation technology and coupled to statistical experimental design and parallel experimentation have enabled the acceleration of chemical process development across multiple industries. HT technologies are often applied to interrogate wide, oft...

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Bibliographic Details
Published in:Annual review of chemical and biomolecular engineering 2017-06, Vol.8 (1), p.525-547
Main Authors: Selekman, Joshua A, Qiu, Jun, Tran, Kristy, Stevens, Jason, Rosso, Victor, Simmons, Eric, Xiao, Yi, Janey, Jacob
Format: Article
Language:English
Subjects:
Animals
Bioengineering - instrumentation
Bioengineering - methods
design of experiments
Drug Discovery - instrumentation
Drug Discovery - methods
Equipment Design
High-Throughput Screening Assays - instrumentation
High-Throughput Screening Assays - methods
Humans
laboratory automation
miniaturization
parallel experimentation
process optimization
Technology, Pharmaceutical - instrumentation
Technology, Pharmaceutical - methods
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Description
Summary:High-throughput (HT) techniques built upon laboratory automation technology and coupled to statistical experimental design and parallel experimentation have enabled the acceleration of chemical process development across multiple industries. HT technologies are often applied to interrogate wide, often multidimensional experimental spaces to inform the design and optimization of any number of unit operations that chemical engineers use in process development. In this review, we outline the evolution of HT technology and provide a comprehensive overview of how HT automation is used throughout different industries, with a particular focus on chemical and pharmaceutical process development. In addition, we highlight the common strategies of how HT automation is incorporated into routine development activities to maximize its impact in various academic and industrial settings.
ISSN:1947-5438
1947-5446
DOI:10.1146/annurev-chembioeng-060816-101411