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High-Throughput Automation in Chemical Process Development
High-throughput (HT) techniques built upon laboratory automation technology and coupled to statistical experimental design and parallel experimentation have enabled the acceleration of chemical process development across multiple industries. HT technologies are often applied to interrogate wide, oft...
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| Published in: | Annual review of chemical and biomolecular engineering 2017-06, Vol.8 (1), p.525-547 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-a451t-bb67b8111c7810b70ee392d9d913a97e8b994ce5c0052444791f265142db36ac3 |
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| cites | cdi_FETCH-LOGICAL-a451t-bb67b8111c7810b70ee392d9d913a97e8b994ce5c0052444791f265142db36ac3 |
| container_end_page | 547 |
| container_issue | 1 |
| container_start_page | 525 |
| container_title | Annual review of chemical and biomolecular engineering |
| container_volume | 8 |
| creator | Selekman, Joshua A Qiu, Jun Tran, Kristy Stevens, Jason Rosso, Victor Simmons, Eric Xiao, Yi Janey, Jacob |
| description | High-throughput (HT) techniques built upon laboratory automation technology and coupled to statistical experimental design and parallel experimentation have enabled the acceleration of chemical process development across multiple industries. HT technologies are often applied to interrogate wide, often multidimensional experimental spaces to inform the design and optimization of any number of unit operations that chemical engineers use in process development. In this review, we outline the evolution of HT technology and provide a comprehensive overview of how HT automation is used throughout different industries, with a particular focus on chemical and pharmaceutical process development. In addition, we highlight the common strategies of how HT automation is incorporated into routine development activities to maximize its impact in various academic and industrial settings. |
| doi_str_mv | 10.1146/annurev-chembioeng-060816-101411 |
| format | article |
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| identifier | ISSN: 1947-5438 |
| ispartof | Annual review of chemical and biomolecular engineering, 2017-06, Vol.8 (1), p.525-547 |
| issn | 1947-5438 1947-5446 |
| language | eng |
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| source | Annual Reviews Open Access |
| subjects | Animals Bioengineering - instrumentation Bioengineering - methods design of experiments Drug Discovery - instrumentation Drug Discovery - methods Equipment Design High-Throughput Screening Assays - instrumentation High-Throughput Screening Assays - methods Humans laboratory automation miniaturization parallel experimentation process optimization Technology, Pharmaceutical - instrumentation Technology, Pharmaceutical - methods |
| title | High-Throughput Automation in Chemical Process Development |
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