Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia

Objective: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF). Methods: Placental tissues and maternal blood samples from...

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Published in:Hypertension in pregnancy 2017-04, Vol.36 (2), p.175-185
Main Authors: Ehrlich, Laura, Hoeller, Alice, Golic, Michaela, Herse, Florian, Perschel, Frank H., Henrich, Wolfgang, Dechend, Ralf, Huppertz, Berthold, Verlohren, Stefan
Format: Article
Language:English
Subjects:
Adult
Case-Control Studies
Female
Fetal Growth Retardation - blood
Humans
intra uterine growth restriction
Placenta - metabolism
Placenta Growth Factor - blood
placental growth factor
PlGF
Pre-Eclampsia - blood
Preeclampsia
Pregnancy
sFlt1
souble fms-like tyrosine kinase
Vascular Endothelial Growth Factor Receptor-1 - blood
Young Adult
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Summary:Objective: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF). Methods: Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity. Results: Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased. Conclusion: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.
ISSN:1064-1955
1525-6065
DOI:10.1080/10641955.2017.1291673