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Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia
Objective: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF). Methods: Placental tissues and maternal blood samples from...
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| Published in: | Hypertension in pregnancy 2017-04, Vol.36 (2), p.175-185 |
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| Main Authors: | , , , , , , , , |
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| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c498t-b3a11967c7488adb7629d5309ab0c0becb8252d3a2a585d3bd2fc44d1d508a113 |
| container_end_page | 185 |
| container_issue | 2 |
| container_start_page | 175 |
| container_title | Hypertension in pregnancy |
| container_volume | 36 |
| creator | Ehrlich, Laura Hoeller, Alice Golic, Michaela Herse, Florian Perschel, Frank H. Henrich, Wolfgang Dechend, Ralf Huppertz, Berthold Verlohren, Stefan |
| description | Objective: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF).
Methods: Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity.
Results: Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased.
Conclusion: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels. |
| doi_str_mv | 10.1080/10641955.2017.1291673 |
| format | article |
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Methods: Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity.
Results: Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased.
Conclusion: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.</description><identifier>ISSN: 1064-1955</identifier><identifier>EISSN: 1525-6065</identifier><identifier>DOI: 10.1080/10641955.2017.1291673</identifier><identifier>PMID: 28494189</identifier><language>eng</language><publisher>England: Taylor & Francis</publisher><subject>Adult ; Case-Control Studies ; Female ; Fetal Growth Retardation - blood ; Humans ; intra uterine growth restriction ; Placenta - metabolism ; Placenta Growth Factor - blood ; placental growth factor ; PlGF ; Pre-Eclampsia - blood ; Preeclampsia ; Pregnancy ; sFlt1 ; souble fms-like tyrosine kinase ; Vascular Endothelial Growth Factor Receptor-1 - blood ; Young Adult</subject><ispartof>Hypertension in pregnancy, 2017-04, Vol.36 (2), p.175-185</ispartof><rights>2017 Taylor & Francis 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c498t-b3a11967c7488adb7629d5309ab0c0becb8252d3a2a585d3bd2fc44d1d508a113</citedby><cites>FETCH-LOGICAL-c498t-b3a11967c7488adb7629d5309ab0c0becb8252d3a2a585d3bd2fc44d1d508a113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28494189$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ehrlich, Laura</creatorcontrib><creatorcontrib>Hoeller, Alice</creatorcontrib><creatorcontrib>Golic, Michaela</creatorcontrib><creatorcontrib>Herse, Florian</creatorcontrib><creatorcontrib>Perschel, Frank H.</creatorcontrib><creatorcontrib>Henrich, Wolfgang</creatorcontrib><creatorcontrib>Dechend, Ralf</creatorcontrib><creatorcontrib>Huppertz, Berthold</creatorcontrib><creatorcontrib>Verlohren, Stefan</creatorcontrib><title>Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia</title><title>Hypertension in pregnancy</title><addtitle>Hypertens Pregnancy</addtitle><description>Objective: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF).
Methods: Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity.
Results: Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased.
Conclusion: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.</description><subject>Adult</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Fetal Growth Retardation - blood</subject><subject>Humans</subject><subject>intra uterine growth restriction</subject><subject>Placenta - metabolism</subject><subject>Placenta Growth Factor - blood</subject><subject>placental growth factor</subject><subject>PlGF</subject><subject>Pre-Eclampsia - blood</subject><subject>Preeclampsia</subject><subject>Pregnancy</subject><subject>sFlt1</subject><subject>souble fms-like tyrosine kinase</subject><subject>Vascular Endothelial Growth Factor Receptor-1 - blood</subject><subject>Young Adult</subject><issn>1064-1955</issn><issn>1525-6065</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNp9kF1LHDEUhoNU1Nr-hJb5A7Pmcya5a5GuLggtqNfh5EtHssmQzNL678266mWvzuHked_Ag9A3glcES3xB8MCJEmJFMRlXhCoyjOwInRFBRT_gQXxqe2P6PXSKPtf6hBvJuThBp1RyxYlUZ-h2k2zxUL3r5gjWpwViV9dx6Ulndku3S_YR0kN7_hOv1p3_Nxdf65RTN6UuwuL7nKpfunb2NsJ2rhN8QccBYvVf3-Y5ul__uru87m9-X20uf970liu59IYBIWoY7cilBGfGgSonGFZgsMXGWyOpoI4BBSGFY8bRYDl3xAksW5Sdo82h12V40nOZtlCedYZJvx5yedBQlslGr0EIacmoguEDB_DSi2BGsNQGFgbDWpc4dNmSay0-fPQRrPfC9btwvReu34S33PdDbt6ZrXcfqXfDDfhxAKYUctnC31yi0ws8x1xCgWSnqtn__3gBhwuQDw</recordid><startdate>20170403</startdate><enddate>20170403</enddate><creator>Ehrlich, Laura</creator><creator>Hoeller, Alice</creator><creator>Golic, Michaela</creator><creator>Herse, Florian</creator><creator>Perschel, Frank H.</creator><creator>Henrich, Wolfgang</creator><creator>Dechend, Ralf</creator><creator>Huppertz, Berthold</creator><creator>Verlohren, Stefan</creator><general>Taylor & Francis</general><general>Taylor & Francis Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>DOA</scope></search><sort><creationdate>20170403</creationdate><title>Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia</title><author>Ehrlich, Laura ; Hoeller, Alice ; Golic, Michaela ; Herse, Florian ; Perschel, Frank H. ; Henrich, Wolfgang ; Dechend, Ralf ; Huppertz, Berthold ; Verlohren, Stefan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c498t-b3a11967c7488adb7629d5309ab0c0becb8252d3a2a585d3bd2fc44d1d508a113</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Fetal Growth Retardation - blood</topic><topic>Humans</topic><topic>intra uterine growth restriction</topic><topic>Placenta - metabolism</topic><topic>Placenta Growth Factor - blood</topic><topic>placental growth factor</topic><topic>PlGF</topic><topic>Pre-Eclampsia - blood</topic><topic>Preeclampsia</topic><topic>Pregnancy</topic><topic>sFlt1</topic><topic>souble fms-like tyrosine kinase</topic><topic>Vascular Endothelial Growth Factor Receptor-1 - blood</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ehrlich, Laura</creatorcontrib><creatorcontrib>Hoeller, Alice</creatorcontrib><creatorcontrib>Golic, Michaela</creatorcontrib><creatorcontrib>Herse, Florian</creatorcontrib><creatorcontrib>Perschel, Frank H.</creatorcontrib><creatorcontrib>Henrich, Wolfgang</creatorcontrib><creatorcontrib>Dechend, Ralf</creatorcontrib><creatorcontrib>Huppertz, Berthold</creatorcontrib><creatorcontrib>Verlohren, Stefan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Hypertension in pregnancy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ehrlich, Laura</au><au>Hoeller, Alice</au><au>Golic, Michaela</au><au>Herse, Florian</au><au>Perschel, Frank H.</au><au>Henrich, Wolfgang</au><au>Dechend, Ralf</au><au>Huppertz, Berthold</au><au>Verlohren, Stefan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia</atitle><jtitle>Hypertension in pregnancy</jtitle><addtitle>Hypertens Pregnancy</addtitle><date>2017-04-03</date><risdate>2017</risdate><volume>36</volume><issue>2</issue><spage>175</spage><epage>185</epage><pages>175-185</pages><issn>1064-1955</issn><eissn>1525-6065</eissn><abstract>Objective: To investigate whether differences between late-onset preeclampsia (PE) and intrauterine growth restriction (IUGR) can be explained by differential placental expression patters of sFlt-1, Flt-1, and placental growth factor (PlGF).
Methods: Placental tissues and maternal blood samples from seven patients with PE, five IUGR, and seven age-matched controls were studied for mRNA and protein levels as well as protein localization and expression intensity.
Results: Placental PlGF mRNA and protein expression were not altered by placental dysfunction while placental villous trophoblast expression intensity of PlGF was increased.
Conclusion: High sFlt-1 concentrations may account for diminished maternal serum PlGF levels.</abstract><cop>England</cop><pub>Taylor & Francis</pub><pmid>28494189</pmid><doi>10.1080/10641955.2017.1291673</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1064-1955 |
| ispartof | Hypertension in pregnancy, 2017-04, Vol.36 (2), p.175-185 |
| issn | 1064-1955 1525-6065 |
| language | eng |
| recordid | cdi_pubmed_primary_28494189 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adult Case-Control Studies Female Fetal Growth Retardation - blood Humans intra uterine growth restriction Placenta - metabolism Placenta Growth Factor - blood placental growth factor PlGF Pre-Eclampsia - blood Preeclampsia Pregnancy sFlt1 souble fms-like tyrosine kinase Vascular Endothelial Growth Factor Receptor-1 - blood Young Adult |
| title | Increased placental sFlt-1 but unchanged PlGF expression in late-onset preeclampsia |
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