A facile one-step method for preparation of Fe 3 O 4 /CS/INH nanoparticles as a targeted drug delivery for tuberculosis

In this paper, Fe O /chitosan/isoniazid magnetic nanoparticles (Fe O /CS/INH-MNPs) were prepared as an environmental stimuli-responsive drug-delivery system by automated in situ click technology, in which Fe O magnetic nanoparticles, chitosan and isoniazid were simultaneously in situ crystallized by...

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Bibliographic Details
Published in:Materials science & engineering. C, Materials for biological applications Materials for biological applications, 2017-08, Vol.77, p.1182
Main Authors: Zhao, Chili, Liu, Xun, Zhang, Xia, Yan, Hong, Qian, Zhilei, Li, Xinghui, Ma, Zhenye, Han, Qiaorong, Pei, Chonghua
Format: Article
Language:English
Subjects:
Chitosan
Drug Delivery Systems
Ferric Compounds
Humans
Isoniazid
Metal Nanoparticles
Tuberculosis
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Summary:In this paper, Fe O /chitosan/isoniazid magnetic nanoparticles (Fe O /CS/INH-MNPs) were prepared as an environmental stimuli-responsive drug-delivery system by automated in situ click technology, in which Fe O magnetic nanoparticles, chitosan and isoniazid were simultaneously in situ crystallized by one-step method. The Fe O magnetic nanoparticles and tripolyphosphate act as stable crosslinkers to produce numerous intermolecular crosslinkages for the mobility of the chitosan chains. Characterization results indicated that the multifunctional drug delivery system with optimized size, excellent loading capacity, well magnetic properties, nontoxicity and pH triggered drug release property is expected to be applied in tuberculosis treatment with excellent magnetic sensitivity and sustained release.
ISSN:1873-0191