Advances in new psychoactive substances identification: the U.R.I.To.N. Consortium

Identification of new psychoactive substances (NPS) in biological and non-biological samples represents a hard challenge for forensic toxicologists. Their great chemical variety and the speed with which new NPS are synthesised and spread make stringent the need of advanced tools for their detection...

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Bibliographic Details
Published in:Journal of enzyme inhibition and medicinal chemistry 2017-01, Vol.32 (1), p.841-849
Main Authors: Bertol, Elisabetta, Vaiano, Fabio, Mari, Francesco, Di Milia, Maria Grazia, Bua, Silvia, Supuran, Claudiu T., Carta, Fabrizio
Format: Article
Language:English
Subjects:
Benzofuran
Chromatography
Chromatography, Liquid
Drug abuse
drugs
Forensic science
Gas chromatography
Indoles
Liquid chromatography
Magnetic Resonance Spectroscopy
Mass spectrometry
Mass spectroscopy
Molecular Structure
multi-analytical approach
Nervous system
New psychoactive substances
NMR
Nuclear magnetic resonance
Psychotropic Drugs - analysis
Psychotropic Drugs - chemical synthesis
Research Paper
Scientific imaging
Tandem Mass Spectrometry
Toxicology
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Summary:Identification of new psychoactive substances (NPS) in biological and non-biological samples represents a hard challenge for forensic toxicologists. Their great chemical variety and the speed with which new NPS are synthesised and spread make stringent the need of advanced tools for their detection based on multidisciplinary approaches. For this reason, in August 2016, the "Unit of Research and Innovation in Forensic Toxicology and Neuroscience of Addiction" (U.R.I.To.N.) was founded by the Forensic Toxicology Division of the University of Florence. In this Research Unit, various professionals (i.e. forensic toxicologists, chemists, physicians) collaborate to study all the aspects of drugs of abuse, especially NPS. Herein, we describe the multidisciplinary approach comprising liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS), gas chromatography hyphenated to mass spectrometry (GC-MS) and solution nuclear magnetic resonance analysis that allowed the identification of three NPS such as 1-(benzofuran-5-yl)-N-methylpropan-2-amine, 2-amino-1-(4-bromo-2,5-dimethoxyphenyl)ethan-1-one (bk-2C-B), and 3-(2-aminopropyl)indole (α-methyltryptamine) in seized materials.
ISSN:1475-6366
1475-6374
DOI:10.1080/14756366.2017.1333987