Aromatic C-H amination: a radical approach for adding new functions into biology- and materials-oriented aromatics

C-H amination is the most powerful method to directly add nitrogen functionalities into a variety of arenes including biology- and materials-oriented molecules. Recent developments in aromatic C-H amination chemistry have enabled the conversion of unactivated arenes into a range of arylamine derivat...

Full description

Saved in:
Bibliographic Details
Published in:Organic & biomolecular chemistry 2017-08, Vol.15 (29), p.671-675
Main Authors: Murakami, Kei, Perry, Gregory J. P, Itami, Kenichiro
Format: Article
Language:English
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:C-H amination is the most powerful method to directly add nitrogen functionalities into a variety of arenes including biology- and materials-oriented molecules. Recent developments in aromatic C-H amination chemistry have enabled the conversion of unactivated arenes into a range of arylamine derivatives without using directing groups or excess amounts of arenes. The key for such successful transformations is the catalytic generation of nitrogen or arene radical intermediates. In this perspective, we discuss recent developments in the radical C-H amination of aromatic molecules. We believe the resulting arylamines, which are hitherto difficult to access, will exhibit unexplored functions for biological and materials application. Recent developments in the radical C-H amination of biology- and materials-oriented aromatics are summarized in this perspective.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob00985b