Choroidal and Retinal Anatomical Responses Following Systemic Corticosteroid Therapy in Vogt-Koyanagi-Harada Disease Using Swept-Source Optical Coherence Tomography

• Published in: Ocular immunology and inflammation 2019-02, Vol.27 (2), p.235-243
• Main Authors: Jaisankar, Durgasri, Raman, Rajiv, Sharma, Hitesh R., Khandelwal, Neha, Bhende, Muna, Agrawal, Rupesh, Sridharan, Sudharshan, Biswas, Jyotirmay
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Choroid - drug effects; Choroid - pathology; Choroidal and retinal thicknesses; choroidal vascularity index; Female; Follow-Up Studies; Glucocorticoids - therapeutic use; Humans; Male; Methylprednisolone - therapeutic use; Middle Aged; Retina - pathology; Retrospective Studies; swept- source optical coherence tomography; systemic steroid response; Tomography, Optical Coherence - methods; Uveomeningoencephalitic Syndrome - diagnosis; Uveomeningoencephalitic Syndrome - drug therapy; Visual Acuity; Vogt-Koyanagi-Harada disease; Young Adult
• ISSN: 0927-3948; 1744-5078
• DOI: 10.1080/09273948.2017.1332231

Purpose: To assess structural changes in retina and choroid after systemic corticosteroid therapy in Vogt-Koyanagi-Harada (VKH) disease using swept-source optical coherence tomography (SS-OCT). Methods: SS-OCT was conducted before treatment and during first-month follow-up in 16 eyes treated with systemic corticosteroids for active VKH. Retina was divided into five zones depending on pretreatment choroidal thickness (CT) of 100 to 200 to 300 to 400μm, and changes in retinal thickness and CT after treatment in these zones were compared with baseline. Results: Mean CT significantly improved from 83.1±8.75 to 156.4±62.73μm(p = 0.008) in the zone with pre-CT 300μm. Conclusions: We have shown choroidal remodeling in VKH. SS-OCT can serve as an important noninvasive tool in assessment of treatment response in patients with VKH disease.