Haematological influences of potassium adaptation in normotensive and renally-hypertensive Wistar rats

Dietary potassium is known to cause reduction in blood pressure in several models of hypertension in human and animal studies but its haematological effects are not known. Here, experiments are designed to study the haematological effects of potassium adaptation (achieved by administering 0.75% KCl...

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Bibliographic Details
Published in:British journal of biomedical science 2002-01, Vol.59 (2), p.80
Main Authors: Ozolua, R I, Omogbai, E K I, Famodu, A B, Ebeigbe, A B, Ajayi, O I
Format: Article
Language:English
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Summary:Dietary potassium is known to cause reduction in blood pressure in several models of hypertension in human and animal studies but its haematological effects are not known. Here, experiments are designed to study the haematological effects of potassium adaptation (achieved by administering 0.75% KCl solution in drinking water for five weeks) in Wistar rats. The animals are divided into four groups comprising controls, potassium-adapted, renal hypertensive, and renal hypertensive with later adaptation to potassium. Packed cell volume (PCV) and platelet count (PC), whole blood and plasma viscosities, and platelet aggregation in the presence of sodium nitroprusside, levcromakalim, and glibenclamide, are studied. Results showed comparable PCV and PC in all groups. While relative whole blood viscosity was significantly higher (P
ISSN:0967-4845
DOI:10.1080/09674845.2002.11783639