Giant Magnetoresistive Biosensor Array for Detecting Magnetorelaxation

In this paper, a time-domain magnetorelaxometry biosensing scheme is presented using giant magnetoresistive (GMR) sensors to measure the fast relaxation response of superparamagnetic magnetic nanoparticles (MNPs) in a pulsed magnetic field. The system consists of an 8 × 10 GMR sensor array, a Helmho...

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Bibliographic Details
Published in:IEEE transactions on biomedical circuits and systems 2017-08, Vol.11 (4), p.755-764
Main Authors: Xiahan Zhou, Chih-Cheng Huang, Hall, Drew A.
Format: Article
Language:English
Subjects:
Biosensing Techniques
Biosensors
Coils
Customization
Disk drives
Electromagnet driver
Giant magnetoresistance
Giant magnetoresistance sensing devices
Hard disks
Immunoassay
Kinetics
Magnetic circuits
magnetic correlated double sampling
Magnetic Fields
Magnetic induction
magnetic nanoparticles
Magnetic resonance
Magnetic sensors
Magnetics
magnetorelaxometry biosensing
magnetoresistive sensors
Magnetoresistivity
Nanoparticles
Nanoparticles - analysis
Noise levels
Nonlinear systems
Sensor arrays
Sensors
Switches
Temperature sensors
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Summary:In this paper, a time-domain magnetorelaxometry biosensing scheme is presented using giant magnetoresistive (GMR) sensors to measure the fast relaxation response of superparamagnetic magnetic nanoparticles (MNPs) in a pulsed magnetic field. The system consists of an 8 × 10 GMR sensor array, a Helmholtz coil, an electromagnet driver, and an integrator-based analog front-end needed to capture the fast relaxation dynamics of MNPs. A custom designed electromagnet driver and Helmholtz coil improve the switch-off speed to >5 Oe/μs, limiting the dead zone time to
ISSN:1932-4545
1940-9990
DOI:10.1109/TBCAS.2017.2682080