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Effects of Vitamin D 2 Supplementation on Vitamin D 3 Metabolism in Health and CKD
Vitamin D supplements are prescribed to correct low circulating concentrations of 25-hydroxyvitamin D. In CKD, vitamin D metabolism is complicated by decreased conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D by CYP27B1 and possibly decreased conversion of 25-hydroxyvitamin D to 24,25-di...
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Published in: | Clinical journal of the American Society of Nephrology 2017-09, Vol.12 (9), p.1498 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
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Summary: | Vitamin D supplements are prescribed to correct low circulating concentrations of 25-hydroxyvitamin D. In CKD, vitamin D metabolism is complicated by decreased conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D by CYP27B1 and possibly decreased conversion of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D by CYP24A1. The aim of this study was to determine the effects of vitamin D
supplementation on vitamin D metabolism in health and CKD.
We conducted a treatment-only intervention study of 25 individuals with CKD (eGFR |
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ISSN: | 1555-905X |
DOI: | 10.2215/CJN.00530117 |