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Effects of Vitamin D 2 Supplementation on Vitamin D 3 Metabolism in Health and CKD

Vitamin D supplements are prescribed to correct low circulating concentrations of 25-hydroxyvitamin D. In CKD, vitamin D metabolism is complicated by decreased conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D by CYP27B1 and possibly decreased conversion of 25-hydroxyvitamin D to 24,25-di...

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Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2017-09, Vol.12 (9), p.1498
Main Authors: Batacchi, Zona, Robinson-Cohen, Cassianne, Hoofnagle, Andrew N, Isakova, Tamara, Kestenbaum, Bryan, Martin, Kevin J, Wolf, Myles S, de Boer, Ian H
Format: Article
Language:English
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Summary:Vitamin D supplements are prescribed to correct low circulating concentrations of 25-hydroxyvitamin D. In CKD, vitamin D metabolism is complicated by decreased conversion of 25-hydroxyvitamin D to 1,25-dihydroxyvitamin D by CYP27B1 and possibly decreased conversion of 25-hydroxyvitamin D to 24,25-dihydroxyvitamin D by CYP24A1. The aim of this study was to determine the effects of vitamin D supplementation on vitamin D metabolism in health and CKD. We conducted a treatment-only intervention study of 25 individuals with CKD (eGFR
ISSN:1555-905X
DOI:10.2215/CJN.00530117