Inhalation Bioassay Chemistry—Walton Horizontal Smoking Machine for Inhalation Exposure of Rodents to Cigarette Smoke

Studies of experimental tobacco smoke carcino-genesis have suffered from the lack of a conveniently available and well-characterized device for exposing animals to tobacco smoke for Inhalation. The Walton Horizontal Smoking Machine, a commercially available system designed to expose up to 20 mice to...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1979-08, Vol.63 (2), p.441-448
Main Authors: Guerin, Michael R., Stokely, James R., Higgins, Cecil E., Moneyhun, Jack H., Holmberg, Robert W.
Format: Article
Language:English
Subjects:
Animals
Biological Assay
Carbon Monoxide - administration & dosage
Chromatography, Gas
Mice
Mice, Inbred Strains
Nicotine - administration & dosage
Research Design
Smoking - complications
Time Factors
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Summary:Studies of experimental tobacco smoke carcino-genesis have suffered from the lack of a conveniently available and well-characterized device for exposing animals to tobacco smoke for Inhalation. The Walton Horizontal Smoking Machine, a commercially available system designed to expose up to 20 mice to the smoke of a single cigarette, may fulfill this need. This system produced a uniform smoke aerosol of predictable concentration and appropriate composition for cigarettes with high delivery of nicotine (40 mg total particulate matter, 2.6 mg nicotine, and 17 cm3 carbon monoxide per cigarette) and with low delivery of nicotine (30 mg total particulate matter, 0.3 mg nicotine, and 17 cm3 carbon monoxide). In this experiment C57BL and DBA/2Bd strains of mice were used. Limitations of the concept of exposing animals to standing smoke were defined.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/63.2.441