Clinical, physical, physiological, and dietary patterns of obese and sedentary adults with primary hypertension characterized by sex and cardiorespiratory fitness: EXERDIET-HTA study

• Published in: Clinical and experimental hypertension (1993) 2018-02, Vol.40 (2), p.141-149
• Main Authors: Gorostegi-Anduaga, Ilargi, Corres, Pablo, Jurio-Iriarte, Borja, Martínez-Aguirre, Aitor, Pérez-Asenjo, Javier, Aispuru, Gualberto R., Arenaza, Lide, Romaratezabala, Estibaliz, Arratibel-Imaz, Iñaki, Mujika, Iñigo, Francisco-Terreros, Silvia, Maldonado-Martín, Sara
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alanine Transaminase - blood; Aspartate Aminotransferases - blood; Blood Pressure; Body Mass Index; Cardiorespiratory Fitness; cardiovascular risk; Cholesterol, HDL - blood; dietary pattern; Exercise Test; Female; gamma-Glutamyltransferase - blood; Health Status; Healthy Diet; Humans; Hypertension - complications; Hypertension - physiopathology; Male; metabolically abnormal obese; Middle Aged; Obesity - complications; Obesity - physiopathology; Patient Compliance; Physical Exertion - physiology; Risk Factors; Sedentary Lifestyle; sex differences; Sex Factors; Triglycerides - blood; Young Adult
• ISSN: 1064-1963; 1525-6006
• DOI: 10.1080/10641963.2017.1346111

The main purpose of this study was to determine some key physical, physiological, clinical, and nutritional markers of health status in obese and sedentary adults (54.0 ± 8.1 years, 141 men and 68 women) with primary hypertension (HTN) characterized by sex and cardiorespiratory fitness (CRF) level. The studied population showed a high cardiovascular risk (CVR) profile including metabolically abnormal obese, with poor CRF level (22.5 ± 5.6 mL·kg −1 ·min −1 ), exercise-induced HTN (Systolic Blood Pressure>210 mmHg in men and >190 mmHg in women at the end of the exercise test) and with non-healthy adherence to dietary pattern (Dietary Approaches to Stop Hypertension, 46.3%; Mediterranean Diet, 41.1%; and Healthy Diet Indicator, 37.1%). Women showed a better biochemical and dietary pattern profile than men (lower values, P < 0.05, in triglycerides, mean difference = 26.3; 95% CI = 0.9-51.7 mg/dL, aspartate transaminase, mean difference = 4.2; 95% CI = 0.3-8.0 U/L; alanine transaminase, mean difference = 8.2; 95% CI = 1.6-14.8 U/L; gamma-glutamyl transpeptidase, mean difference = 11.0; 95% CI = -1.1-23.2 U/L and higher values, P = 0.002, in high-density lipoprotein cholesterol, mean difference = 5.0, 95% CI = -13.3-3.3 mg/dL), but physical and peak exercise physiological characteristics were poorer. A higher CRF level might contribute to the attenuation of some CVR factors, such as high body mass index, non-dipping profile, and high hepatic fat. The results strongly suggest that targeting key behaviors such as improving nutritional quality and CRF via regular physical activity will contribute to improving the health with independent beneficial effects on CVR factors.