Lessons from Interspecies Mammalian Chimeras

As chimeras transform from beasts of Greek mythology into tools of contemporary bioscience, secrets of developmental biology and evolutionary divergence are being revealed. Recent advances in stem cell biology and interspecies chimerism have generated new models with extensive basic and translationa...

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Bibliographic Details
Published in:Annual review of cell and developmental biology 2017-10, Vol.33 (1), p.203-217
Main Authors: Suchy, Fabian, Nakauchi, Hiromitsu
Format: Article
Language:English
Subjects:
Animals
chimera
Chimera - metabolism
Humans
interspecies
Mammals - metabolism
organ niche
Organogenesis
pluripotency
Species Specificity
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Summary:As chimeras transform from beasts of Greek mythology into tools of contemporary bioscience, secrets of developmental biology and evolutionary divergence are being revealed. Recent advances in stem cell biology and interspecies chimerism have generated new models with extensive basic and translational applications, including generation of transplantable, patient-specific organs.
ISSN:1081-0706
1530-8995
DOI:10.1146/annurev-cellbio-100616-060654