The acute effects of ultraviolet radiation on the blood transcriptome are independent of plasma 25OHD 3

The molecular basis of many health outcomes attributed to solar ultraviolet radiation (UVR) is unknown. We tested the hypothesis that they may originate from transcriptional changes in blood cells. This was determined by assessing the effect of fluorescent solar simulated radiation (FSSR) on the tra...

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Bibliographic Details
Published in:Environmental research 2017-11, Vol.159, p.239
Main Authors: Bustamante, Mariona, Hernandez-Ferrer, Carles, Sarria, Yaris, Harrison, Graham I, Nonell, Lara, Kang, Wenjing, Friedländer, Marc R, Estivill, Xavier, González, Juan R, Nieuwenhuijsen, Mark, Young, Antony R
Format: Article
Language:English
Subjects:
Adult
Blood - metabolism
Calcifediol - blood
Humans
Male
Transcriptome
Ultraviolet Rays - adverse effects
United Kingdom
Vitamins - blood
Young Adult
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Summary:The molecular basis of many health outcomes attributed to solar ultraviolet radiation (UVR) is unknown. We tested the hypothesis that they may originate from transcriptional changes in blood cells. This was determined by assessing the effect of fluorescent solar simulated radiation (FSSR) on the transcriptional profile of peripheral blood pre- and 6h, 24h and 48h post-exposure in nine healthy volunteers. Expression of 20 genes was down-regulated and one was up-regulated at 6h after FSSR. All recovered to baseline expression at 24h or 48h. These genes have been associated with immune regulation, cancer and blood pressure; health effects attributed to vitamin D via solar UVR exposure. Plasma 25-hydroxyvitamin D [25OHD ] levels increased over time after FSSR and were maximal at 48h. The increase was more pronounced in participants with low basal 25OHD levels. Mediation analyses suggested that changes in gene expression due to FSSR were independent of 25OHD and blood cell subpopulations.
ISSN:1096-0953