Inability of mitogen-induced liver hyperplasia to support the induction of enzyme-altered Islands induced by liver carcinogens

Experiments were designed to determine whether liver cell proliferation induced by direct mitogens is as effective as compensatory cell proliferation consequent to previous cell loss, in supporting the growth of enzyme-altered islands in the liver induced by chemical carcinogens. Male Wistar rats we...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1987-11, Vol.47 (21), p.5557-5559
Main Authors: COLUMBANO, A, LEDDA-COLUMBANO, G. M, LEE, G, RAJALAKSHMI, S, SARMA, D. S. R
Format: Article
Language:English
Subjects:
Animals
Applied sciences
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Cell Division
Chemical agents
Exact sciences and technology
gamma-Glutamyltransferase - analysis
Hepatectomy
Hyperplasia
Liver - enzymology
Liver - pathology
Liver Neoplasms, Experimental - chemically induced
Liver Neoplasms, Experimental - enzymology
Male
Medical sciences
Mitogens - pharmacology
Other techniques and industries
Rats
Rats, Inbred Strains
Tumors
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Summary:Experiments were designed to determine whether liver cell proliferation induced by direct mitogens is as effective as compensatory cell proliferation consequent to previous cell loss, in supporting the growth of enzyme-altered islands in the liver induced by chemical carcinogens. Male Wistar rats were given injections of a single nonnecrogenic dose of N-methyl-N-nitrosourea or benzo(a)pyrene during the S phase following the administration of four different liver mitogens, namely, lead nitrate, ethylene dibromide, nafenopin, and cyproterone acetate, or during compensatory cell proliferation following partial hepatectomy or a necrogenic dose of CCl4. The carcinogen-altered hepatocytes were monitored as gamma-glutamyltransferase- or placental glutathione S-transferase-positive foci using a 2-wk promoting regimen consisting of 0.03% 2-acetylaminofluorene coupled with a necrogenic dose of CCl4. The results indicate that, unlike compensatory cell proliferation induced by partial hepatectomy or CCl4, the mitogen-induced cell proliferation did not result in a significant number of enzyme-altered islands, despite the fact that the extent of cell proliferation at the time of carcinogen administration, as monitored by the examination of labeled cells, is similar with both types of proliferative stimuli.
ISSN:0008-5472
1538-7445