Chemistry and radiochemistry of As, Re and Rh isotopes relevant to radiopharmaceutical applications: high specific activity radionuclides for imaging and treatment

The chemistry and radiochemistry of high specific activity radioisotopes of arsenic, rhenium and rhodium are reviewed with emphasis on University of Missouri activities over the past several decades, and includes recent results. The nuclear facilities at the University of Missouri (10 MW research re...

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Bibliographic Details
Published in:Dalton transactions : an international journal of inorganic chemistry 2017, Vol.46 (42), p.14677-1469
Main Authors: Feng, Yutian, Phelps, Tim E, Carroll, Valerie, Gallazzi, Fabio, Sieckman, Gary, Hoffman, Timothy J, Barnes, Charles L, Ketring, Alan R, Hennkens, Heather M, Jurisson, Silvia S
Format: Article
Language:English
Subjects:
Arsenic - chemistry
Chemistry
Models, Molecular
Molecular Conformation
Radiochemistry
Radioisotopes - chemistry
Radiopharmaceuticals - chemistry
Rhenium - chemistry
Rhodium - chemistry
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Summary:The chemistry and radiochemistry of high specific activity radioisotopes of arsenic, rhenium and rhodium are reviewed with emphasis on University of Missouri activities over the past several decades, and includes recent results. The nuclear facilities at the University of Missouri (10 MW research reactor and 16.5 MeV GE PETtrace cyclotron) allow research and development into novel theranostic radionuclides. The production, separation, enriched target recovery, radiochemistry, and chelation chemistry of 72,77 As, 186,188 Re and 105 Rh are discussed. Advances in production, separation, target recovery, and chelation chemistry of high specific activity radionuclides will promote new theranostic agent development.
ISSN:1477-9226
1477-9234
DOI:10.1039/c7dt02407j