Clinical Usefulness of Coronary Flow Reserve Ratio for the Detection of Significant Coronary Artery Disease on 13 N-Ammonia Positron Emission Tomography

This study aimed to evaluate the diagnostic performance of coronary flow reserve (CFR), hyperemic myocardial blood flow (hMBF), and CFR ratio for detecting significant coronary artery disease (CAD) on N-ammonia positron emission tomography (PET). We analyzed 63 patients (mean age, 71±9 years; 43 mal...

Full description

Saved in:
Bibliographic Details
Published in:Circulation journal : official journal of the Japanese Circulation Society 2018-01, Vol.82 (2), p.486
Main Authors: Kawaguchi, Naoto, Okayama, Hideki, Kawamura, Go, Shigematsu, Tatsuya, Takahashi, Tatsunori, Kawada, Yoshitaka, Hiasa, Go, Yamada, Tadakatsu, Matsuoka, Hiroshi, Kazatani, Yukio, Miyagawa, Masao, Mochizuki, Teruhito
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Ammonia
Coronary Artery Disease - diagnosis
Coronary Circulation
Female
Fractional Flow Reserve, Myocardial
Humans
Hyperemia - physiopathology
Male
Middle Aged
Nitrogen Radioisotopes
Positron-Emission Tomography - methods
ROC Curve
Sensitivity and Specificity
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to evaluate the diagnostic performance of coronary flow reserve (CFR), hyperemic myocardial blood flow (hMBF), and CFR ratio for detecting significant coronary artery disease (CAD) on N-ammonia positron emission tomography (PET). We analyzed 63 patients (mean age, 71±9 years; 43 males) with suspected CAD who underwent both pharmacological stress/rest N-ammonia PET and coronary angiography. CFR and hMBF for PET were calculated automatically using quantitative PET software, and the CFR ratio was defined as the ratio of per-vessel CFR to maximum CFR in a standard 17-segment model. We compared the diagnostic performance among the 3 quantitative values. In the per-vessel analysis, 55 vessels were diagnosed as significant CAD (≥70% stenosis and/or fraction flow reserve ≤0.8). CFR, hMBF, and CFR ratio of significant CAD were significantly lower than for non-significant CAD (1.85±0.69 vs. 2.38±0.69; P
ISSN:1347-4820