Enhanced surface acoustic wave cell sorting by 3D microfluidic-chip design

We demonstrate an acoustic wave driven microfluidic cell sorter that combines advantages of multilayer device fabrication with planar surface acoustic wave excitation. We harness the strong vertical component of the refracted acoustic wave to enhance cell actuation by using an asymmetric flow field...

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Bibliographic Details
Published in:Lab on a chip 2017-11, Vol.17 (23), p.459-469
Main Authors: Ung, W. L, Mutafopulos, K, Spink, P, Rambach, R. W, Franke, T, Weitz, D. A
Format: Article
Language:English
Subjects:
Actuation
Design parameters
Fluorescence
Surface acoustic waves
Three dimensional flow
Wave excitation
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Summary:We demonstrate an acoustic wave driven microfluidic cell sorter that combines advantages of multilayer device fabrication with planar surface acoustic wave excitation. We harness the strong vertical component of the refracted acoustic wave to enhance cell actuation by using an asymmetric flow field to increase cell deflection. Precise control of the 3-dimensional flow is realized by topographical structures implemented on the top of the microchannel. We experimentally quantify the effect of the structure dimensions and acoustic parameter. The design attains cell sorting rates and purities approaching those of state of the art fluorescence-activated cell sorters with all the advantages of microfluidic cell sorting. We demonstrate an acoustic wave driven microfluidic cell sorter that combines advantages of multilayer device fabrication with planar surface acoustic wave excitation.
ISSN:1473-0197
1473-0189
DOI:10.1039/c7lc00715a