Prospective memory impairment in idiopathic REM sleep behavior disorder

Objective: The aim of the present study was to investigate if prospective memory (PM) is impaired in idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). RBD is a parasomnia characterized by dream enactment and by REM sleep without muscle atonia. iRBD is considered as the initial stag...

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Published in:Clinical neuropsychologist 2018-07, Vol.32 (5), p.1019-1037
Main Authors: Bezdicek, Ondrej, Nikolai, Tomáš, Nepožitek, Jiří, Peřinová, Pavla, Kemlink, David, Dušek, Pavel, Příhodová, Iva, Dostálová, Simona, Ibarburu, Veronika, Trnka, Jiří, Kupka, Karel, Mecková, Zuzana, Keller, Jiří, Vymazal, Josef, Růžička, Evžen, Šonka, Karel, Dušek, Petr
Format: Article
Language:English
Subjects:
Activities of Daily Living - psychology
Aged
episodic memory
Female
Humans
Male
Memory Disorders - diagnostic imaging
Memory Disorders - epidemiology
Memory Disorders - psychology
Memory, Episodic
Middle Aged
neurodegenerative disease
Neuropsychological Tests
parasomnia
Polysomnography - methods
prospective memory
REM sleep behavior disorder
REM Sleep Behavior Disorder - diagnostic imaging
REM Sleep Behavior Disorder - epidemiology
REM Sleep Behavior Disorder - psychology
synucleinopathy
Tomography, Emission-Computed, Single-Photon - methods
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Summary:Objective: The aim of the present study was to investigate if prospective memory (PM) is impaired in idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). RBD is a parasomnia characterized by dream enactment and by REM sleep without muscle atonia. iRBD is considered as the initial stage of neurodegeneration with pathological storage of alpha-synuclein. Method: Sixty iRBD patients with polysomnography-confirmed RBD without parkinsonism and dementia and 30 demographically matched normal controls (NC) were enrolled in the present study. Clinical assessment included Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), dopamine transporter single-photon emission computed tomography (DaT-SPECT) for imaging synapses of dopaminergic neurons in the striatum and a neuropsychological battery with embedded time-based and event-based PM measures. Results: iRBD differed significantly from NC in event-based PM, a number of event-based failures to recall intention and total PM performance (all p 
ISSN:1385-4046
1744-4144
DOI:10.1080/13854046.2017.1394493