Retinal Vascular Caliber Changes After Topical Nepafenac Treatment for Diabetic Macular Edema

• Published in: Current eye research 2018-03, Vol.43 (3), p.357-361
• Main Authors: Evliyaoğlu, Ferhat, Akpolat, Çetin, Kurt, Muhammed Mustafa, Çekiç, Osman, Nuri Elçioğlu, Mustafa
• Format: Article
• Language: English
• Subjects: Administration, Topical; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Benzeneacetamides - administration & dosage; Diabetic Macular Edema; Diabetic Retinopathy - complications; Diabetic Retinopathy - drug therapy; Diabetic Retinopathy - physiopathology; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Macular Edema - drug therapy; Macular Edema - etiology; Macular Edema - physiopathology; Male; Middle Aged; Nepafenac; NSAIDs; Phenylacetates - administration & dosage; Prospective Studies; Retinal Vessel Caliber; Retinal Vessels - diagnostic imaging; Retinal Vessels - drug effects; Retinal Vessels - physiopathology; Tomography, Optical Coherence; Topical; Visual Acuity
• ISSN: 0271-3683; 1460-2202
• DOI: 10.1080/02713683.2017.1399425

Purpose: To assess changes in retinal vascular caliber in response to short-term use of nepafenac eye drops in patients with mild diabetic macular edema. Materials and methods: Thirty-four patients with previously untreated bilateral mild diabetic macular edema were included in this prospective study. For each participant, one eye was randomly assigned to nepafenac treatment (0.1%, three times/day) and the other eye was left untreated throughout the study. Using digital fundus photographs, retinal vascular calibers were calculated and compared in treated and untreated eyes at the baseline, week 1, and week 6. Results: Baseline vessel diameters did not differ in treated and fellow eyes (p > 0.05). Over the 6 weeks of the study, significant vasoconstriction of the retinal arteriolar caliber was observed at weeks 1 (p