Comparison of DWI and 18 F-FDG PET/CT for assessing preoperative N-staging in gastric cancer: evidence from a meta-analysis

• Published in: Oncotarget 2017-10, Vol.8 (48), p.84473
• Main Authors: Luo, Mingxu, Song, Hongmei, Liu, Gang, Lin, Yikai, Luo, Lintao, Zhou, Xin, Chen, Bo
• Format: Article
• Language: English
• ISSN: 1949-2553

The diagnostic values of diffusion weighted imaging (DWI) and F-fluorodeoxyglucose positron emission tomography/computed tomography ( F-FDG PET/CT) for N-staging of gastric cancer (GC) were identified and compared. After a systematic search to identify relevant articles, meta-analysis was used to summarize the sensitivities, specificities, and areas under curves (AUCs) for DWI and PET/CT. To better understand the diagnostic utility of DWI and PET/CT for N-staging, the performance of multi-detector computed tomography (MDCT) was used as a reference. Fifteen studies were analyzed. The pooled sensitivity, specificity, and AUC with 95% confidence intervals of DWI were 0.79 (0.73-0.85), 0.69 (0.61-0.77), and 0.81 (0.77-0.84), respectively. For PET/CT, the corresponding values were 0.52 (0.39-0.64), 0.88 (0.61-0.97), and 0.66 (0.62-0.70), respectively. Comparison of the two techniques revealed DWI had higher sensitivity and AUC, but no difference in specificity. DWI exhibited higher sensitivity but lower specificity than MDCT, and F-FDG PET/CT had lower sensitivity and equivalent specificity. Overall, DWI performed better than F-FDG PET/CT for preoperative N-staging in GC. When the efficacy of MDCT was taken as a reference, DWI represented a complementary imaging technique, while F-FDG PET/CT had limited utility for preoperative N-staging.