Haemolytic anaemia and hepatocitolysis associated with hypermagnesaemia by repeated exposures to copper-calcium fungicides

For the medical practice, our manuscript acts as a signal, despite only presenting three cases which feature the association between hepatocytolysis, haemolysis and hypermagnesaemia. This clinical-biologic triad was highlighted with the workers who through the nature of their profession were exposin...

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Bibliographic Details
Published in:Journal of enzyme inhibition and medicinal chemistry 2018-01, Vol.33 (1), p.184-189
Main Authors: Bălăeţ, Constantin, Coculescu, Bogdan Ioan, Bălăeţ, Maria, Manole, Gheorghe, Dincă, Gabi Valeriu
Format: Article
Language:English
Subjects:
Adult
Anemia, Hemolytic - chemically induced
Anemia, Hemolytic - complications
Calcium Hydroxide - administration & dosage
Calcium Hydroxide - adverse effects
Calcium Hydroxide - chemistry
Copper Sulfate - administration & dosage
Copper Sulfate - adverse effects
Copper Sulfate - chemistry
Copper-calcium fungicide
Erythropoiesis - drug effects
Fungicides, Industrial - administration & dosage
Fungicides, Industrial - adverse effects
Fungicides, Industrial - chemistry
haemolysis
hepatocytic cytolysis
Humans
hypercupraemia
hypermagnesaemia
Hypocalcemia - chemically induced
Hypocalcemia - complications
ineffective erythropoiesis
Liver - drug effects
Liver - metabolism
Male
Middle Aged
oxidative stress
Research Paper
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Summary:For the medical practice, our manuscript acts as a signal, despite only presenting three cases which feature the association between hepatocytolysis, haemolysis and hypermagnesaemia. This clinical-biologic triad was highlighted with the workers who through the nature of their profession were exposing themselves periodically to vapours which contained copper sulphate neutralised with calcium hydroxide, a fungicide used for fruit trees. We are exclusively assessing the haematological perturbation. In this aetiological context, the generating mechanism for haemolysis is very probable biochemical, where hypercupraemia interferes with cellular antioxidant defence mechanisms. Hypothetically, the role of the redox homeostasis disorder in the intravascular destruction of erythrocytes is sustained, and particularly the coexistence of cell cytolysis in the medullary erythroid compartment, which can be assimilated with a possible ineffective erythropoiesis.
ISSN:1475-6366
1475-6374
DOI:10.1080/14756366.2017.1409745