Clinical and immunological parallels in pregnancy loss

Peculiar characteristics of cytotoxic endometrial cells' response depending on the clinical aspects (frequency, gestational age, form of miscarriage, hysteroscopic pattern) have been studied. Patients with pregnancy loss in their past medical history demonstrate a decreased level of CD8 + lymph...

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Bibliographic Details
Published in:Gynecological endocrinology 2017-12, Vol.33 (sup1), p.5-7
Main Authors: Mamedaliyeva, N. M., Kurmanova, A. M., Lokshin, V. N., Kurmanova, G. M., Sh. Issenova, S.
Format: Article
Language:English
Subjects:
cytotoxic lymphocytes
index СD56+/СD16+ and СD8+/СD16
Miscarriage
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Summary:Peculiar characteristics of cytotoxic endometrial cells' response depending on the clinical aspects (frequency, gestational age, form of miscarriage, hysteroscopic pattern) have been studied. Patients with pregnancy loss in their past medical history demonstrate a decreased level of CD8 + lymphocytes, and the decrease is exacerbated as the incidence of miscarriages increases and in the presence of endometrial hypoplasia. The content of CD16 + lymphocytes increases in comparison with the control group, however, there is a reducing trend of this phenotype of killers as the incidence of miscarriages increases and in the presence of endometrial hypoplasia. Reduction of CD56 + lymphocytes progresses with repeated pregnancy loss and endometrial hyperplasia.
ISSN:0951-3590
1473-0766
DOI:10.1080/09513590.2017.1404238