Carcinogenicity of Halogenated Olefinic and Aliphatic Hydrocarbons in Mice

A series of 15 halogenated hydrocarbons of industrial and environmental importance were tested for carcinogenicity by chronic administration by one or more routes in Ha:ICR Swiss mice. Not all compounds were tested by the four routes of administration used. Allyl chloride, 1,2-dibromo-3-chloropropan...

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Bibliographic Details
Published in:JNCI : Journal of the National Cancer Institute 1979-12, Vol.63 (6), p.1433-1439
Main Authors: Van Duuren, Benjamin L., Goldschmidt, Bernard M., Loewengart, Gordon, Smith, Ann C., Melchionne, Susan, Seidman, Irving, Roth, Daniel
Format: Article
Language:English
Subjects:
Animals
Carcinogens, Environmental
Cocarcinogenesis
Drug Evaluation, Preclinical
Female
Hydrocarbons, Halogenated - toxicity
Lung Neoplasms - chemically induced
Male
Mice
Neoplasms, Experimental - chemically induced
Papilloma - chemically induced
Sarcoma, Experimental - chemically induced
Skin Neoplasms - chemically induced
Stomach Neoplasms - chemically induced
Structure-Activity Relationship
Tetradecanoylphorbol Acetate
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Summary:A series of 15 halogenated hydrocarbons of industrial and environmental importance were tested for carcinogenicity by chronic administration by one or more routes in Ha:ICR Swiss mice. Not all compounds were tested by the four routes of administration used. Allyl chloride, 1,2-dibromo-3-chloropropane, and vinylidene chloride were active as skin tumor initiators in the two-stage carcinogenesis assays; phorbol myristate acetate was used as a promoter. 1,2-Dibromoethane was the only compound that induced a significant incidence (P0.05: trichloroethylene, tetrachloroethylene, hexachlorobutadiene, chloroacetaldehyde, 1-chloropropene oxide (cis and trans), and trichloroethylene oxide.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/63.6.1433