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Role of histamine H 1 receptor in caffeine induced locomotor sensitization
The present study elucidated the role of histamine H receptor in the caffeine induced locomotor sensitization. Intermittent administration of caffeine (15 mg/kg, i.p.) on alternate days (induction phase) i.e. 1 , 3 , 5 , 7 , 9 , 11 and 13 resulted in the development of locomotor sensitization. In ad...
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Published in: | Neuroscience letters 2018-03, Vol.668, p.60 |
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Main Authors: | , , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | The present study elucidated the role of histamine H
receptor in the caffeine induced locomotor sensitization. Intermittent administration of caffeine (15 mg/kg, i.p.) on alternate days (induction phase) i.e. 1
, 3
, 5
, 7
, 9
, 11
and 13
resulted in the development of locomotor sensitization. In addition, challenge with sub-stimulant dose of caffeine (10 mg/kg, i.p.) directly on 17
day to induction group animals resulted in expression to locomotor sensitization to caffeine. I.c.v. injection of histaminergic agents concomitantly with caffeine during induction phase i.e. histamine H
receptor agonist, FMPH (6.5 μg/mouse) significantly potentiated while H
receptor antagonist, cetirizine (0.1 μg/mouse) attenuated the locomotor sensitization induced by caffeine (15 mg/kg, i.p.). In addition, challenge with caffeine (10 mg/kg, i.p.) on the expression day (17
) to the induction group mice on FMPH + caffeine treatment showed enhanced, while those on cetirizine + caffeine treatment exhibited lesser expression to locomotor sensitization. Therefore, a possible contributory role of the central histaminergic system via H
receptor stimulation or up-regulation in the caffeine-induced locomotor sensitizing effect is proposed. |
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ISSN: | 1872-7972 |
DOI: | 10.1016/j.neulet.2018.01.002 |