Action and Toxicity of Cyclosporine

Cyclosporine is a potent new immunosuppressive agent that has proven particularly useful in organ transplantation. The unique action of the drug on T-cell immunity without myelosuppression is summarized. Cyclosporine pharmacology and adverse reactions, particularly nephrotoxicity, are reviewed in th...

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Bibliographic Details
Published in:Annual review of medicine 1986-01, Vol.37 (1), p.215-224
Main Authors: Bennett, W M, Norman, D J
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Biological and medical sciences
Blood Coagulation Disorders - chemically induced
Cyclosporins - adverse effects
Cyclosporins - blood
Cyclosporins - metabolism
Cyclosporins - pharmacology
Gingival Hyperplasia - chemically induced
Graft Rejection
Heart Transplantation
Hirsutism - chemically induced
Humans
Immunomodulators
Kidney - drug effects
Kidney Diseases - chemically induced
Kidney Transplantation
Liver - drug effects
Lymphoma - chemically induced
Medical sciences
Nervous System - drug effects
Pharmacology. Drug treatments
T-Lymphocytes - drug effects
T-Lymphocytes, Helper-Inducer - drug effects
T-Lymphocytes, Regulatory - drug effects
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Summary:Cyclosporine is a potent new immunosuppressive agent that has proven particularly useful in organ transplantation. The unique action of the drug on T-cell immunity without myelosuppression is summarized. Cyclosporine pharmacology and adverse reactions, particularly nephrotoxicity, are reviewed in this paper.
ISSN:0066-4219
1545-326X
DOI:10.1146/annurev.me.37.020186.001243