Translating secondary electrospray ionization-high-resolution mass spectrometry to the clinical environment

While there has been progress in making use of breath tests to guide clinical decision making, the full potential of exhaled breath analysis still remains to be exploited. Here we summarize some of the reasons why this is the case, what we have done so far to overcome some of the existing obstacles,...

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Bibliographic Details
Published in:Journal of breath research 2018-02, Vol.12 (2), p.027113-027113
Main Authors: Singh, Kapil Dev, del Miguel, Guillermo Vidal, Gaugg, Martin Thomas, Ibañez, Alfredo J, Zenobi, Renato, Kohler, Malcolm, Frey, Urs, Sinues, Pablo M-L
Format: Article
Language:English
Subjects:
biomarker discovery
Biomarkers
Biomarkers - analysis
Breath Tests
Follow-Up Studies
Humans
Ions
Mass spectrometry
Pilot Projects
real-time analyis
Scientific imaging
secondary electrospray ionization-mass spectrometry
Spectrometry, Mass, Electrospray Ionization - methods
Translational Medical Research
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Summary:While there has been progress in making use of breath tests to guide clinical decision making, the full potential of exhaled breath analysis still remains to be exploited. Here we summarize some of the reasons why this is the case, what we have done so far to overcome some of the existing obstacles, and our vision of how we think breath analysis will play a more prominent role in the coming years. In particular, we envision that real-time high-resolution mass spectrometry will provide valuable information in biomarker discovery studies. However, this can only be achieved by a coordinated effort, using standardized equipment and methods in multi-center studies to eventually deliver tangible advances in the field of breath analysis in a clinical setting. Concrete aspects such as sample integrity, compound identification, quantification and standardization are discussed. Novel secondary electrospray ionization developments with the aim of facilitating inter-groups comparisons and biomarker validation studies are also presented.
ISSN:1752-7163
1752-7155
1752-7163
DOI:10.1088/1752-7163/aa9ee3