Comparison of the effect of daily versus bolus dose maternal vitamin D 3 supplementation on the 24,25-dihydroxyvitamin D 3 to 25-hydroxyvitamin D 3 ratio

Supplementing lactating mothers with high doses of vitamin D can adequately meet vitamin D requirements of the breastfed infant. We compared the effect of bolus versus daily vitamin D dosing in lactating mothers on vitamin D catabolism. We hypothesized that catabolism of 25(OH)D to 24,25(OH) D would...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2018-05, Vol.110, p.321
Main Authors: Ketha, Hemamalini, Thacher, Tom D, Oberhelman, Sara S, Fischer, Philip R, Singh, Ravinder J, Kumar, Rajiv
Format: Article
Language:English
Subjects:
24,25-Dihydroxyvitamin D 3 - blood
Adult
Calcifediol - blood
Chromatography, Liquid
Dietary Supplements
Female
Humans
Infant
Lactation - drug effects
Tandem Mass Spectrometry
Vitamin D - administration & dosage
Young Adult
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Summary:Supplementing lactating mothers with high doses of vitamin D can adequately meet vitamin D requirements of the breastfed infant. We compared the effect of bolus versus daily vitamin D dosing in lactating mothers on vitamin D catabolism. We hypothesized that catabolism of 25(OH)D to 24,25(OH) D would be greater in the bolus than in the daily dose group. Randomized controlled trial (clinicaltrials.govNCT01240265) in 40 lactating women. Subjects were randomized to receive vitamin D orally, either a single dose of 150,000IU or 5000IU daily for 28days. Vitamin D metabolites were measured in serum and breast milk at baseline, 1, 3, 7, 14 and 28days. Temporal changes in the serum 24,25(OH) D /25(OH)D ratio. The concentration of serum 24,25(OH) D was directly related to that of 25(OH)D in both groups (r =0.63; p
ISSN:1873-2763
DOI:10.1016/j.bone.2018.02.024