Abnormal mTOR Activation in Autism

The mechanistic target of rapamycin (mTOR) is an important signaling hub that integrates environmental information regarding energy availability and stimulates anabolic molecular processes and cell growth. Abnormalities in this pathway have been identified in several syndromes in which autism spectr...

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Bibliographic Details
Published in:Annual review of neuroscience 2018-07, Vol.41 (1), p.1-23
Main Authors: Winden, Kellen D, Ebrahimi-Fakhari, Darius, Sahin, Mustafa
Format: Article
Language:English
Subjects:
Autism
Cell growth
Clinical trials
fragile X
mTOR
PTEN
Rapamycin
TOR protein
Tuberculosis
tuberous sclerosis
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Summary:The mechanistic target of rapamycin (mTOR) is an important signaling hub that integrates environmental information regarding energy availability and stimulates anabolic molecular processes and cell growth. Abnormalities in this pathway have been identified in several syndromes in which autism spectrum disorder (ASD) is highly prevalent. Several studies have investigated mTOR signaling in developmental and neuronal processes that, when dysregulated, could contribute to the development of ASD. Although many potential mechanisms still remain to be fully understood, these associations are of great interest because of the clinical availability of mTOR inhibitors. Clinical trials evaluating the efficacy of mTOR inhibitors to improve neurodevelopmental outcomes have been initiated.
ISSN:0147-006X
1545-4126
DOI:10.1146/annurev-neuro-080317-061747