New secoiridoids from the fruits of Ligustrum lucidum

Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6′-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis. Among them, 1 featured a rare rearrangement product o...

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Bibliographic Details
Published in:Journal of asian natural products research 2018-05, Vol.20 (5), p.431-438
Main Authors: Qiu, Zuo-Cheng, Zhao, Xiao-Xiao, Wu, Qing-Chang, Fu, Jian-Wu, Dai, Yi, Wong, Man-Sau, Yao, Xin-Sheng
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Cell proliferation
Chemical bonds
Fruits
ligustri lucidi fructus
Ligustrum lucidum
MC3T3-E1 cells
Oleaceae
Organic chemistry
Osteoblasts
osteogenic activity
secoiridoids
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Summary:Three new secoiridoids, nuezhenelenoliciside (1), isojaslanceoside B (2), 6′-O-trans-cinnamoyl-secologanoside (3), were isolated from the dried fruits of Ligustrum lucidum. Their structures were elucidated by comprehensive spectroscopic analysis. Among them, 1 featured a rare rearrangement product of secoiridoid, which underwent the cleavage of chemical bond between C-1 and O-2, and the reformation of a new iridoid ring between C-8 and O-2. In addition, all compounds were tested for their osteogenic activity on pre-osteoblastic MC3T3-E1 cells. As a result, 1 and 3 exhibited potent effects on promoting cell proliferation of pre-osteoblast cells.
ISSN:1028-6020
1477-2213
DOI:10.1080/10286020.2018.1454438