Hemostatic factors in rabbit limb lymph: relationship to mechanisms regulating extravascular coagulation

Mechanisms regulating extravascular coagulation in interstitial fluids of peripheral tissues are poorly understood, since measurements of hemostatic factors in these fluids are unavailable. Because lymph from a body region reflects the composition of its interstitial fluid, we measured hemostatic fa...

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Published in:American journal of physiology. Heart and circulatory physiology 1998-03, Vol.274 (3), p.H769
Main Authors: Le, Dzung T, Borgs, Peter, Toneff, Thomas W, Witte, Marlys H, Rapaport, Samuel I
Format: Article
Language:English
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Summary:Mechanisms regulating extravascular coagulation in interstitial fluids of peripheral tissues are poorly understood, since measurements of hemostatic factors in these fluids are unavailable. Because lymph from a body region reflects the composition of its interstitial fluid, we measured hemostatic factors in limb lymph of rabbits both as activity and as antigen. Mean lymph-to-plasma activity ratios were the following: fibrinogen, 0.28; prothrombin, 0.26; factor X, 0.27; factor VII, 0.17; and factors V and VIII, 0.08. All lymph fibrinogen was clottable; fibrin degradation products were absent. Lymph von Willebrand factor antigen was
ISSN:1522-1539